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Quisqualic Acid

Known as: 1,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-, Quisqualic Acid [Chemical/Ingredient] 
An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (1)

Excitatory Amino Acid Agonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

Quisqualatehomoquisqualaminehomoquisqualic acidquisqualamine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Mutation-induced Quisqualic Acid and Ibotenic Acid Affinity at the Metabotropic Glutamate Receptor Subtype 4
The metabotropic glutamate receptors (mGluRs) are key modulators of excitatory neurotransmission in the central nervous system… 
2004
2004
Quinolinic acid stimulates luteinizing hormone secretion in female rats: evidence for involvement of N-methyl-D-aspartate-preferring receptors
SummaryPharmacological evidence suggests that endogenous excitatory amino acid neurotransmitters stimulate luteinizing hormone… 
2001
2001
NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain.
Brain inflammation underlies the pathogenesis of Alzheimer's disease (AD) and nonsteroidal anti-inflammatory drug therapy may… 
1996
1996
An indirect cholinesterase inhibitor, metrifonate, increases neocortical EEG arousal in rats
WE investigated the ability of a cholinesterase inhibitor, metrifonate, to desynchronize cortical EEG activity. Metrifonate… 
1995
1995
Characterization of metabotropic glutamate receptor‐stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells
1 The pharmacology of excitatory amino acid (EAA)‐stimulated phosphoinositide (PI) hydrolysis, monitored via [3H]‐inositol… 
1992
1992
Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.
In this report, a novel bioisostere of the alpha-amino acid, 3,4-diamino-3-cyclobutene-1,2-dione, has been incorporated into a… 
1990
1990
Neonatal Excitotoxic Brain Injury
The mechanism of brain injury caused by excitotoxins has been explored in detail in the adult, but not the developing animal. To… 
1984
1984
Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.
A number of analogues of ibotenic acid [(RS)-3-hydroxy-5- isoxazoleglycine ] were synthesized; they were tested as excitants on… 
1983
1983
[Rapid hippocampal kindling following intraamygdaloid injection of quisqualic acid in cats].
Quisqualic acid (QA) is a potent neuroexcitant and a heterocyclic analogue of glutamate as is kainic acid. Twenty micrograms of… 
1975
1975
[Studies on the constituents of Quisqualis Fructus. II. Structure of quisqualic acid (author's transl)].
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