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Central pattern generators and the control of rhythmic movements
Central pattern generators are neuronal circuits that when activated can produce rhythmic motor patterns such as walking, breathing, flying, and swimming in the absence of sensory or descending… Expand
Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs.
It is known that (a) neuromodulatory substances reconfigure circuit dynamics by altering synaptic strength and voltage-dependent conductances and (b) individual neurons can switch among different functional circuits. Expand
Principles of rhythmic motor pattern generation.
Cellular, circuit, and computational analyses of the mechanisms underlying the generation of rhythmic movements in both invertebrate and vertebrate nervous systems are discussed. Expand
Similar network activity from disparate circuit parameters
It is found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity. Expand
Variability, compensation and homeostasis in neuron and network function
Examples from theoretical and experimental studies of invertebrates and vertebrates are used to explore several issues relevant to understanding the precision of tuning of synaptic and intrinsic currents for the operation of functional neuronal circuits. Expand
Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons.
- A. Prinz, Cyrus P. Billimoria, E. Marder
- Computer Science, Medicine
- Journal of neurophysiology
- 1 December 2003
A database of about 1.7 million single-compartment model neurons is generated by independently varying 8 maximal membrane conductances based on measurements from lobster stomatogastric neurons and it is demonstrated how the database can be screened for models that reproduce the behavior of a specific biological neuron and show that the contents can give insight into the way a neuron's membrane conductance values determine its activity pattern and response properties. Expand
Multiple models to capture the variability in biological neurons and networks
It is argued that instead of trying to build a single model that captures the generic behavior of a neuron or circuit, it is beneficial to construct a population of models that capture the behavior of the population that provided the experimental data. Expand
Neuromodulation of Neuronal Circuits: Back to the Future
- E. Marder
- Medicine, Biology
- 4 October 2012
The anatomical connectome provides a minimal structure and the neuromodulatory environment constructs and specifies the functional circuits that give rise to behavior. Expand
Multiple Peptides Converge to Activate the Same Voltage-Dependent Current in a Central Pattern-Generating Circuit
Voltage clamp data indicate that all six substances converge onto the same voltage-dependent current, although they activate different receptors, and differential network responses evoked by these substances may primarily depend on the receptor distribution on network neurons. Expand
Global Structure, Robustness, and Modulation of Neuronal Models
- M. Goldman, J. Golowasch, E. Marder, L. Abbott
- Physics, Medicine
- The Journal of Neuroscience
- 15 July 2001
A global analysis of the structure of a conductance-based model neuron finds correlates of this dual robustness and sensitivity in this model, which implies that neuromodulators that alter a sensitive set of conductances will have powerful, and possibly state-dependent, effects. Expand