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Quinine

Known as: (R)-(-)-Quinine, Quinine [Chemical/Ingredient], 6'-Methoxycinchonidine 
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona… Expand
National Institutes of Health

Related topics

Related topics

44 relations

Narrower (20)

9-O-(phenyloxycarbonyl)quinineDiapulmonLimptarN-benzylquininium
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Broader (4)

AlkaloidsAnalgesicsAntimalarialsMuscle Relaxants, Central
Cinchona (plant)Drug toxicityIn BloodMalaria
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its… Expand
Highly Cited
2010
Highly Cited
2010
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
Summary Background Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission… Expand
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Highly Cited
2008
Highly Cited
2008
Evidence of artemisinin-resistant malaria in western Cambodia.
To the Editor: Although artemisinins are potent and rapidly acting antimalarial drugs, their widespread use for treating patients… Expand
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Highly Cited
2006
Highly Cited
2006
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)-based… Expand
Highly Cited
2005
Highly Cited
2005
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
BACKGROUND In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of… Expand
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Highly Cited
2005
Highly Cited
2005
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
The emergence and spread of multidrug resistant Plasmodium falciparum has severely limited the therapeutic options for the… Expand
Review
2005
Review
2005
Fungal secondary metabolism — from biochemistry to genomics
Much of natural product chemistry concerns a group of compounds known as secondary metabolites. These low-molecular-weight… Expand
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Review
1998
Review
1998
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
What roles do mesolimbic and neostriatal dopamine systems play in reward? Do they mediate the hedonic impact of rewarding stimuli… Expand
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Review
1996
Review
1996
Pharmacokinetics of Quinine, Chloroquine and Amodiaquine
SummaryMalaria is associated with a reduction in the systemic clearance and apparent volume of distribution of the cinchona… Expand
Highly Cited
1979
Highly Cited
1979
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
A rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against… Expand
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