Quinine

Known as: (R)-(-)-Quinine, Quinine [Chemical/Ingredient], 6'-Methoxycinchonidine 
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub… (More)
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Highly Cited
2006
Highly Cited
2006
Relatively few selective substrate and inhibitor probes have been identified for human UDP-glucuronosyltransferases (UGTs). This… (More)
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Highly Cited
2006
Highly Cited
2006
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)-based… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of… (More)
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Highly Cited
2003
Highly Cited
2003
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing… (More)
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Highly Cited
2002
Highly Cited
2002
Astrocytes are capable of widespread intercellular communication via propagated increases in intracellular Ca(2+) concentration… (More)
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Highly Cited
2001
Highly Cited
2001
We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins… (More)
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Highly Cited
2000
Highly Cited
2000
Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds… (More)
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Review
1996
Review
1996
Malaria is associated with a reduction in the systemic clearance and apparent volume of distribution of the cinchona alkaloids… (More)
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Highly Cited
1978
Highly Cited
1978
One or two bottle preference tests, i.e., relative fluid consumption, constitute the primary methodology for determining… (More)
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