Quinine

Known as: (R)-(-)-Quinine, Quinine [Chemical/Ingredient], 6'-Methoxycinchonidine 
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona… (More)
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (21)

6'-hydroxycinchonidine9-O-(phenyloxycarbonyl)quinineDiapulmonLimptar
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Broader (6)

AlkaloidsAnalgesicsAnalgesics, Non-NarcoticAntimalarials
(More)
Cinchona (plant)Drug toxicityIn BloodMalaria
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
BACKGROUND Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub… (More)
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Highly Cited
2006
Highly Cited
2006
Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) "probes" for human udp…
Relatively few selective substrate and inhibitor probes have been identified for human UDP-glucuronosyltransferases (UGTs). This… (More)
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Highly Cited
2006
Highly Cited
2006
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts to implement artemisinin (ART)-based… (More)
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Highly Cited
2005
Highly Cited
2005
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
BACKGROUND In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of… (More)
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Highly Cited
2003
Highly Cited
2003
Artemisinins target the SERCA of Plasmodium falciparum
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing… (More)
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Highly Cited
2002
Highly Cited
2002
Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels.
Astrocytes are capable of widespread intercellular communication via propagated increases in intracellular Ca(2+) concentration… (More)
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Highly Cited
2001
Highly Cited
2001
Quinine blocks specific gap junction channel subtypes.
We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins… (More)
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Highly Cited
2000
Highly Cited
2000
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds… (More)
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Review
1996
Review
1996
Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.
Malaria is associated with a reduction in the systemic clearance and apparent volume of distribution of the cinchona alkaloids… (More)
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Highly Cited
1978
Highly Cited
1978
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
One or two bottle preference tests, i.e., relative fluid consumption, constitute the primary methodology for determining… (More)
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