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Hydrophilic interaction chromatography.
Synergistic effects on enantioselectivity of zwitterionic chiral stationary phases for separations of chiral acids, bases, and amino acids by HPLC.
TLDR
The corresponding zwitterionic ion-exchange-type chiral stationary phases (CSPs) in fact combined the applicability spectra of the parent chiral ion exchangers allowing for enantioseparations of chiral acids and amine-type solutes in liquid chromatography using polar organic mode with largely rivaling separation factors as compared to the parent WAX and SCX CSPs.
Regulation of oxidized platelet lipidome: implications for coronary artery disease
TLDR
The platelet lipidome in symptomatic coronary artery disease patients and the functional consequences of the chemokine CXCL12 and its receptors CXCR-4/-7 on lipid uptake in platelets are explored, finding an altered platelets might be associated with thrombotic disposition in CAD.
Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.
TLDR
Two reversible inhibitors 11d and 11e of the clinically challenging triple mutant EGFR L858R/T790M/C797S with IC50 values in the low nanomolar range are reported.
Impact of amphiphilic biomass-dissolving ionic liquids on biological cells and liposomes.
TLDR
The more hydrophobic ILs were found to have a major effect on the surface charges and size distributions of the model liposomes, which can lead to disruption of the lipid bilayer, indicating that the cytotoxicity is at least to some extent dependent on direct interactions between ILs and the biomembrane.
Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid
TLDR
Elevated concentration levels were found in real samples; however, EtP seems to be less sensitive compared to the previously known ethanol phase II conjugates EtG and EtS, and the principal potential of EtP as ethanol consumption marker is assessed.
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