Pyrantel

Known as: Pyrantel [Chemical/Ingredient], Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)- 
A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It… (More)
National Institutes of Health

Related topics

Related topics

39 relations
AncylostomiasisAscariasisDrug AllergyEnterobiasis
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Broader (2)

Antinematodal AgentsNeuromuscular Depolarizing Agents

Narrower (10)

CombantrinDrontalExodusLiqui-Vict 2X
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Papers overview

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2009
2009
The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist
BACKGROUND Intestinal parasitic nematodes such as hookworms, Ascaris lumbricoides, and Trichuris trichiura are amongst most… (More)
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2009
2009
Acetylcholine receptor subunit genes from Ancylostoma caninum: altered transcription patterns associated with pyrantel resistance.
The molecular mechanism of resistance to nicotinic agonist anthelmintics such as pyrantel and levamisole in nematodes of medical… (More)
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2008
2008
Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum.
Resistance of the canine hookworm Ancylostoma caninum to anthelmintic therapy with pyrantel is an emerging problem in canine… (More)
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2004
2004
Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris.
Three pharmacological subtypes of cholinergic receptors have been distinguished in Ascaris suum using a muscle contraction assay… (More)
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Highly Cited
2003
Highly Cited
2003
Identification of human cytochrome P450s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data
Knowledge about the metabolism of anti-parasitic drugs (APDs) will be helpful in ongoing efforts to optimise dosage… (More)
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2000
2000
Pyrantel resistance alters nematode nicotinic acetylcholine receptor single-channel properties.
Resistance to the anthelmintics pyrantel ((E)-1,4,5, 6-tetrahydro-1-methyl-2-[2-(2thienyl)ethenyl]pyrimidine) and levamisole ((S… (More)
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Review
1999
Review
1999
Control strategies for human intestinal nematode infections.
In recent years significant progress has been made in understanding the ecology, epidemiology and related morbidity and… (More)
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Highly Cited
1997
Highly Cited
1997
Failure of mebendazole in treatment of human hookworm infections in the southern region of Mali.
Preliminary studies indicated that single-dose (500 mg) mebendazole gave disappointing results in the treatment of hookworm… (More)
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1993
1993
Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus.
Experiments were carried out in the hamster to compare the relative susceptibility of Necator americanus and Ancylostoma… (More)
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1970
1970
Aspects of the pharmacology of a new anthelmintic: pyrantel.
1. The pharmacological properties of an anthelmintic, pyrantel, and some of its analogues have been described and compared with… (More)
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