• Publications
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Concordance of the toxicity of pharmaceuticals in humans and in animals.
This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop (April 1999), which served to betterExpand
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Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses.
  • B. Wood, A. Monro
  • Medicine
  • The British journal of venereal diseases
  • 1 February 1975
Serum concentrations of tinidazole and metronidazole have been measured in healthy female volunteers who received a single dose of 2 g. of each drug in a cross-over study. Bioassays against T.Expand
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Marketed Human Pharmaceuticals Reported to be Tumorigenic in Rodents
The 1994 U.S. Physicians' Desk Reference reports the results of rodent carcinogenicity tests on 241 pharmaceutical agents. Positive results were reported for 101 agents, with a class label implying aExpand
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How useful are chronic (life-span) toxicology studies in rodents in identifying pharmaceuticals that pose a carcinogenic risk to humans?
  • A. Monro
  • Biology, Medicine
  • Adverse drug reactions and toxicological reviews
  • 1993
After 20 years' experience of the chronic rodent bioassay and in the light of our current understanding of the mechanisms of carcinogenesis, there is now a wide recognition that the presentExpand
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Are lifespan rodent carcinogenicity studies defensible for pharmaceutical agents?
  • A. Monro
  • Biology, Medicine
  • Experimental and toxicologic pathology : official…
  • 1 February 1996
For most pharmaceuticals, the assessment of carcinogenic risk to humans can be made from information available from a) genotoxicity studies in vivo, b) 3-6 month toxicology studies in two or moreExpand
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Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half‐life: Interplay of age and diurnal feeding pattern
Doxazosin, an α‐adrenergic blocking agent, has a plasma half‐life in male rats of 1–2 h after i.v. administration. Plasma concentrations of doxazosin were measured in male rats receiving the drugExpand
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The pharmacokinetics, metabolism and tissue distribution of tinidazole.
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The paradoxical lack of interspecies correlation between plasma concentrations and chemical carcinogenicity.
  • A. Monro
  • Chemistry, Medicine
  • Regulatory toxicology and pharmacology : RTP
  • 1 August 1993
Several chemicals have been shown, within the limits of epidemiology, to be thus far not carcinogenic in humans at systemic exposure levels similar to those associated with carcinogenicity inExpand
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Adrenergic neurone blocking agents. II. Some dioxane-substituted derivatives of guanoxan.
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Drug toxicokinetics: scope and limitations that arise from species differences in pharmacodynamic and carcinogenic responses
  • A. Monro
  • Biology, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1 February 1994
Toxicokinetics describes the concentration and time course of a xenobiotic in the circulation under the conditions of a toxicology study. However, the fundamental challenge to the toxicologist, ofExpand
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