Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Concordance of the toxicity of pharmaceuticals in humans and in animals.
- H. Olson, G. Betton, +12 authors A. Heller
- Medicine
- Regulatory toxicology and pharmacology : RTP
- 1 August 2000
This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop (April 1999), which served to better… Expand
Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses.
Serum concentrations of tinidazole and metronidazole have been measured in healthy female volunteers who received a single dose of 2 g. of each drug in a cross-over study. Bioassays against T.… Expand
Marketed Human Pharmaceuticals Reported to be Tumorigenic in Rodents
- T. S. Davies, A. Monro
- Biology
- 1 April 1995
The 1994 U.S. Physicians' Desk Reference reports the results of rodent carcinogenicity tests on 241 pharmaceutical agents. Positive results were reported for 101 agents, with a class label implying a… Expand
How useful are chronic (life-span) toxicology studies in rodents in identifying pharmaceuticals that pose a carcinogenic risk to humans?
- A. Monro
- Biology, Medicine
- Adverse drug reactions and toxicological reviews
- 1993
After 20 years' experience of the chronic rodent bioassay and in the light of our current understanding of the mechanisms of carcinogenesis, there is now a wide recognition that the present… Expand
Are lifespan rodent carcinogenicity studies defensible for pharmaceutical agents?
- A. Monro
- Biology, Medicine
- Experimental and toxicologic pathology : official…
- 1 February 1996
For most pharmaceuticals, the assessment of carcinogenic risk to humans can be made from information available from a) genotoxicity studies in vivo, b) 3-6 month toxicology studies in two or more… Expand
Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half‐life: Interplay of age and diurnal feeding pattern
- C. Charuel, P. Comby, A. Monro
- Chemistry, Medicine
- Journal of applied toxicology : JAT
- 1 February 1992
Doxazosin, an α‐adrenergic blocking agent, has a plasma half‐life in male rats of 1–2 h after i.v. administration. Plasma concentrations of doxazosin were measured in male rats receiving the drug… Expand
The pharmacokinetics, metabolism and tissue distribution of tinidazole.
- B. Wood, J. Faulkner, A. Monro
- Medicine
- The Journal of antimicrobial chemotherapy
- 1982
The paradoxical lack of interspecies correlation between plasma concentrations and chemical carcinogenicity.
- A. Monro
- Chemistry, Medicine
- Regulatory toxicology and pharmacology : RTP
- 1 August 1993
Several chemicals have been shown, within the limits of epidemiology, to be thus far not carcinogenic in humans at systemic exposure levels similar to those associated with carcinogenicity in… Expand
Adrenergic neurone blocking agents. II. Some dioxane-substituted derivatives of guanoxan.
- A. Monro, G. W. Potter
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 September 1967
Drug toxicokinetics: scope and limitations that arise from species differences in pharmacodynamic and carcinogenic responses
- A. Monro
- Biology, Medicine
- Journal of Pharmacokinetics and Biopharmaceutics
- 1 February 1994
Toxicokinetics describes the concentration and time course of a xenobiotic in the circulation under the conditions of a toxicology study. However, the fundamental challenge to the toxicologist, of… Expand