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Concordance of the toxicity of pharmaceuticals in humans and in animals.
- H. Olson, G. Betton, +12 authors A. Heller
- MedicineRegulatory toxicology and pharmacology : RTP
- 1 August 2000
The survey results support the value of in vivo toxicology studies to predict for many significant HTs associated with pharmaceuticals and have helped to identify HT categories that may benefit from improved methods.
Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses.
The longer half-life of tinidazole led to significantly higher serum concentrations (by bioassay and chemical assay) of tinIDazole than of metronidazoles from 6 hrs onwards.
Marketed Human Pharmaceuticals Reported to be Tumorigenic in Rodents
The 1994 U.S. Physicians' Desk Reference reports the results of rodent carcinogenicity tests on 241 pharmaceutical agents, with a class label implying a carcinogenic hazard also attached to 9 estrogenic, 4 androgenic, and 3 progestogenic agents.
Evaluation of the Carcinogenic Potential of Pharmaceuticals
Recognition of the 4 properties (genotoxicity, immunosuppression, steroid hormonal activity and long term tissue damage), at least one of which is associated with each of the pharmaceuticals known to be carcinogenic to humans, should focus more attention on a search for these properties in patients.
How useful are chronic (life-span) toxicology studies in rodents in identifying pharmaceuticals that pose a carcinogenic risk to humans?
- A. Monro
- Biology, MedicineAdverse drug reactions and toxicological reviews
Examination of the pattern of results in the NTP and IARC bioassay databases and the rodent data for 18 chemicals which appear thus far not to be carcinogenic in humans, indicates that data generated in mouse bioassays do not contribute to human carcinogenic risk assessment.
Are lifespan rodent carcinogenicity studies defensible for pharmaceutical agents?
- A. Monro
- Biology, MedicineExperimental and toxicologic pathology : official…
- 1 February 1996
The use of rodents are highly misleading as predictors of human cancer risk and the value of the bioassay is itself questionable.
Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half‐life: Interplay of age and diurnal feeding pattern
- C. Charuel, P. Comby, A. Monro
- Chemistry, MedicineJournal of applied toxicology : JAT
- 1 February 1992
The 24‐h area under the curve (AUC) values increased disproportionately with dose and with age from 2 months up to 8 months of age; thereafter they were fairly stable to 24 years of age, which may have wider toxicokinetic implications.
The pharmacokinetics, metabolism and tissue distribution of tinidazole.
The paradoxical lack of interspecies correlation between plasma concentrations and chemical carcinogenicity.
- A. Monro
- Chemistry, MedicineRegulatory toxicology and pharmacology : RTP
- 1 August 1993
There is usually no scientific basis for using the concentrations of a xenobiotic that occur in body fluids or tissues during a rodent carcinogenicity test to make a quantitative carcinogenic risk assessment in humans, it is argued.
Adrenergic neurone blocking agents. II. Some dioxane-substituted derivatives of guanoxan.