Putative Polycomb Group Protein ASXL1

Known as: ASXL1, Additional Sex Combs-Like Protein 1 
Putative Polycomb group protein ASXL1 (1541 aa, ~165 kDa) is encoded by the human ASXL1 gene. This protein may be involved in the modulation of both… (More)
National Institutes of Health

Related topics

Related topics

7 relations
ASXL1 geneCell NucleusChromatin Remodeling FactorGenes, Regulator
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without… (More)
  • table 1
  • figure 1
  • table 8
  • figure 3
  • table 13
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10-30% of patients with myeloid malignancies, most commonly in… (More)
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Mutations and prognosis in primary myelofibrosis
Patient outcome in primary myelofibrosis (PMF) is significantly influenced by karyotype. We studied 879 PMF patients to determine… (More)
  • table 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
High-throughput DNA sequencing significantly contributed to diagnosis and prognostication in patients with myelodysplastic… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Prognostic score including gene mutations in chronic myelomonocytic leukemia.
PURPOSE Several prognostic scoring systems have been proposed for chronic myelomonocytic leukemia (CMML), a disease in which some… (More)
  • table 2
  • table 1
  • figure 1
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2012
Highly Cited
2012
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute… (More)
Is this relevant?
Highly Cited
2011
Highly Cited
2011
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.
Progression of chronic myelogenous leukemia (CML) to accelerated (AP) and blast phase (BP) is because of secondary molecular… (More)
  • table 1
  • figure 1
  • figure 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Clinical effect of point mutations in myelodysplastic syndromes.
BACKGROUND Myelodysplastic syndromes are clinically heterogeneous disorders characterized by clonal hematopoiesis, impaired… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Review
2010
Review
2010
Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for… (More)
  • figure 1
  • table 1
  • figure 2
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.
The myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal haematological diseases characterized by ineffective… (More)
Is this relevant?