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Putative Polycomb Group Protein ASXL1

Known as: ASXL1, Additional Sex Combs-Like Protein 1 
Putative Polycomb group protein ASXL1 (1541 aa, ~165 kDa) is encoded by the human ASXL1 gene. This protein may be involved in the modulation of both… 
National Institutes of Health

Related topics

Related topics

7 relations
ASXL1 geneCell NucleusChromatin Remodeling FactorGenes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Evaluation by Flow Cytometry of Mature Monocyte Subpopulations for the Diagnosis and Follow-Up of Chronic Myelomonocytic Leukemia
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis… 
2018
2018
Prognostic impact of ASXL1 mutations in patients with myelodysplastic syndromes and multilineage dysplasia with or without ring sideroblasts.
2018
2018
Screening for ASXL1 and SRSF2 mutations is imperative for treatment decision‐making in otherwise low or intermediate‐1 risk patients with myelofibrosis
Chapuy, B., Roemer, M.G., Stewart, C., Tan, Y., Abo, R.P., Zhang, L., Dunford, A.J., Meredith, D.M., Thorner, A.R., Jordanova, E… 
2015
2015
CALR and ASXL1 mutation analysis in 190 patients with essential thrombocythemia
Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm (MPN) characterized by an increased number of platelets… 
2015
2015
Inflammaging-Associated Metabolic Alterations Foster Development of the MDS Genotype
Recent studies suggest that aging-associated inflammation, or "inflammaging", contributes to genetic instability and MDS… 
Review
2013
Review
2013
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Highly Cited
2012
Highly Cited
2012
TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms
Mutations in the TET2 and ASXL1 genes have been described in approximately 14% and 8% of patients, respectively, with classic… 
2012
2012
Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children
Acquired somatic mutations of JAK2 have been reported to play a pivotal role in the pathogenesis of BCR‐ABL1‐negative… 
2012
2012
Histone modification defects in developmental disorders and cancer
Clinically, Weaver syndrome is closely related to Sotos syndrome, which is frequently caused by mutations in NSD1. This gene also… 
2011
2011
Epigenetics and mutations in chronic myeloproliferative neoplasms
The BCR-ABL1-negative classic myeloproliferative neoplasms, polycythemia vera (PV), essential thrombocytemia (ET) and primary… 
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