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- Publications
- Influence
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease
- Eleonora Cianflone, Michele Torella, +6 authors D. Torella
- Biology, Medicine
- Cells
- 1 June 2020
Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and possess the potential to differentiate in all cell types of the organ in which they operate. Adult stem… Expand
Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition
- Nadia Lobello, F. Biamonte, +8 authors F. Costanzo
- Biology, Medicine
- Oncotarget
- 22 August 2016
Objectives Ferritin is the major intracellular iron storage protein essential for maintaining the cellular redox status. In recent years ferritin heavy chain (FHC) has been shown to be involved also… Expand
Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
- I. Aversa, F. Zolea, +10 authors F. Costanzo
- Biology, Medicine
- Journal of experimental & clinical cancer…
- 3 August 2017
BackgroundFerritin plays a central role in the intracellular iron metabolism; the molecule is a nanocage of 24 subunits of the heavy and light types. The heavy subunit (FHC) is provided of a… Expand
MicroRNA let-7g acts as tumor suppressor and predictive biomarker for chemoresistance in human epithelial ovarian cancer
- F. Biamonte, G. Santamaria, +9 authors F. Costanzo
- Medicine
- Scientific Reports
- 5 April 2019
Remarkable deregulation of microRNAs has been demonstrated in epithelial ovarian cancer (EOC). In particular, some of the let-7 miRNA family members have been proposed as tumor suppressors. Here, we… Expand
H-Ferritin-Regulated MicroRNAs Modulate Gene Expression in K562 Cells
- F. Biamonte, F. Zolea, +9 authors F. Costanzo
- Biology, Medicine
- PloS one
- 27 March 2015
In a previous study, we showed that the silencing of the heavy subunit (FHC) offerritin, the central iron storage molecule in the cell, is accompanied by a modification in global gene expression. In… Expand
FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation
- M. Di Sanzo, I. Aversa, +7 authors F. Costanzo
- Biology, Medicine
- PloS one
- 16 March 2016
Ferritin, the major iron storage protein, performs its essential functions in the cytoplasm, nucleus and mitochondria. The variable assembly of 24 subunits of the Heavy (H) and Light (L) type… Expand
H ferritin silencing induces protein misfolding in K562 cells: A Raman analysis.
- F. Zolea, F. Biamonte, +10 authors F. Costanzo
- Biology, Medicine
- Free radical biology & medicine
- 1 December 2015
The redox state of the cell is involved in the regulation of many physiological functions as well as in the pathogenesis of several diseases, and is strictly dependent on the amount of iron in its… Expand
Ferritin heavy subunit enhances apoptosis of non-small cell lung cancer cells through modulation of miR-125b/p53 axis
- F. Biamonte, A. M. Battaglia, +7 authors F. Costanzo
- Chemistry, Medicine
- Cell Death & Disease
- 1 December 2018
Ferritin is a nanocage protein composed by the variable assembly of 24 heavy and light subunits. As major intracellular iron storage protein, ferritin has been studied for many years in the context… Expand
Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
- Duarte Mendes Oliveira, Katia Grillone, +10 authors A. Rizzuto
- Biology, Medicine
- Journal of experimental & clinical cancer…
- 17 April 2018
BackgroundImprovement in genetic characterization of Colon Cancer (CC) patients is required to propose new potential targets, since surgical resection coupled to chemotherapy, presents several limits… Expand
H-Ferritin Affects Cisplatin-Induced Cytotoxicity in Ovarian Cancer Cells through the Modulation of ROS
- A. Salatino, I. Aversa, +10 authors F. Costanzo
- Chemistry, Medicine
- Oxidative medicine and cellular longevity
- 31 October 2019
Reactive oxygen species (ROS) mediates cisplatin-induced cytotoxicity in tumor cells. However, when cisplatin-induced ROS do not reach cytotoxic levels, cancer cells may develop chemoresistance. This… Expand