Purinergic P2X Receptor Agonists
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Ion channels play fundamental roles in both excitable and non-excitable tissues and therefore constitute attractive drug targets… Expand Defensins are the first endogenous mediators to be characterized as alarmins and play multifunctional roles in immune response… Expand Interleukin-1β (IL-1β) is a proinflammatory cytokine and a therapeutic target in several chronic autoimmune states. Monocytes and… Expand Digestion and absorption of nutrients and the secretion and reabsorption of fluid in the gastrointestinal tract are regulated by… Expand The mechanisms of sensory transduction of pulmonary reactive oxygen species (ROS) by capsaicin‐sensitive vagal lung afferent… Expand 1 Using an in vitro single unit recording technique we studied the changes in mechanical and chemical sensitivity of vagal… Expand A cloned P2x-purinoceptor was transiently expressed in single isolated rat adrenal chromaffin cells and evaluated for the… Expand Here we describe a novel purinergic receptor, the P2X5 receptor, cloned from rat heart. The full‐length cDNA encodes a protein… Expand 1 Whole‐cell and outside‐out patch clamp recordings were used to characterize the physiological and pharmacological properties of… Expand Electrophysiological experiments on dissociated smooth muscle and neurons have revealed three distinct phenotypes of P2X receptor… Expand