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The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels
Unanticipated, novel hypothesis on nitric oxide (NO) radical, an inorganic, labile, gaseous molecule, as a neurotransmitter first appeared in late 1989 and into the early 1990s, and solid evidences… Expand
Cerebral Blood Flow Regulation by Nitric Oxide: Recent Advances
Nitric oxide (NO) is undoubtedly quite an important intercellular messenger in cerebral and peripheral hemodynamics. This molecule, formed by constitutive isomers of NO synthase, endothelial… Expand
Determination and bioimaging method for nitric oxide in biological specimens by diaminofluorescein fluorometry.
A simple and sensitive assay and a cellular bioimaging method for nitric oxide (NO) were developed using a novel diaminofluorescein DAF-FM and its diacetate. DAF-FM is converted via an NO-specific… Expand
Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats
We have reported that a deficiency of tetrahydrobiopterin (BH4), an active cofactor of endothelial NO synthase (eNOS), contributes to the endothelial dysfunction through reduced eNOS activity and… Expand
Preganglionic and Postganglionic Neurons Responsible for Cerebral Vasodilation Mediated by Nitric Oxide in Anesthetized Dogs
- N. Toda, K. Ayajiki, T. Tanaka, T. Okamura
- Medicine, Biology
- Journal of cerebral blood flow and metabolism…
- 1 April 2000
The authors performed investigations to functionally determine the route of efferent innervation in vivo responsible for cerebral vasodilation mediated by nitric oxide (NO). In anesthetized beagles,… Expand
How mental stress affects endothelial function
- N. Toda, Megumi Nakanishi-Toda
- Pflügers Archiv - European Journal of Physiology
- 23 September 2011
Mental stress is an important factor contributing to recognized mechanisms underlying cardiovascular events. Among these, stress-related endothelial dysfunction is an early risk factor that predicts… Expand
Vasodilating beta-adrenoceptor blockers as cardiovascular therapeutics.
- N. Toda
- Pharmacology & therapeutics
beta-Adrenoceptor blocking agents (beta-blockers) have been established as therapeutics for treatment of patients with hypertension, ischemic heart diseases, chronic heart failure, arrhythmias, and… Expand
Different responsiveness of prostaglandin D2‐sensitive systems to prostaglandin D2 and its analogues
1 Prostaglandin D2 (PGD2) and six PGD2 analogues were used to classify responsiveness of several PGD2‐sensitive systems. The analogues used were 9β‐PGD2,… Expand
Alpha adrenergic receptor subtypes in human, monkey and dog cerebral arteries.
- N. Toda
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 September 1983
In helical strips of human and monkey cerebral arteries, norepinephrine produced a greater contraction than that in dog cerebral arteries. In monkey cerebral arteries, phenylephrine and… Expand
Mechanisms underlying arginine vasopressin-induced relaxation in monkey isolated coronary arteries.
OBJECTIVE The present study was undertaken to examine whether arginine vasopressin (AVP) relaxes primate coronary artery and to analyse the mechanisms of its action in reference to endothelial nitric… Expand