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Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex
TLDR
It is concluded that ceramide mediates obesity-related vascular dysfunction by a mechanism that involves PP2A-mediated disruption of the eNOS/Akt/Hsp90 signaling complex and provides important insight into a pathway that represents a novel target for reversing obesity- related vascular dysfunction. Expand
Sensory transduction of pulmonary reactive oxygen species by capsaicin‐sensitive vagal lung afferent fibres in rats
TLDR
Both the TRPV1 and P2X receptors mediate the sensory transduction of ROS, especially H2O2 and ·OH, by capsaicin‐sensitive vagal lung afferent fibres. Expand
Afferent vagal pathways mediating respiratory reflexes evoked by ROS in the lungs of anesthetized rats.
TLDR
The results suggest that the H( 2)O(2)-evoked initial and delayed airway reflexes are antagonistic and may result from stimulation of lung C fibers and rapidly adapting receptors, respectively, and the reflex effects of H(2)O (2) are, in part, due to the action of. Expand
Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats.
TLDR
Results showed that infusion of adenosine significantly elevated the sensitivity of pulmonary C-fiber afferents in rat lungs and that this potentiating effect is likely mediated through activation of theAdenosine A1 receptor. Expand
Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability.
TLDR
Findings reveal that autophagy not only plays a critical role in maintaining NO bioavailability, but may also be a key regulator of oxidant-antioxidant balance and inflammatory-anti-inflammatory balance that ultimately regulate endothelial cell responses to shear stress. Expand
Endothelial Cell Autophagy Maintains Shear Stress–Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase
TLDR
Targeted reactivation of purinergic signaling and PKC&dgr; has strategic potential to restore compromised NO generation in pathologies associated with suppressed EC autophagy. Expand
Heat and α1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide.
TLDR
It is revealed for the first time that, in human skeletal muscle feed arteries, NO blockade can restore the heat-attenuated α(1)-adrenergic receptor-mediated vasocontraction and implicate endothelium-derived NO bioavailability as a major contributor to heat-induced sympatholysis. Expand
Hyperthermia increases sensitivity of pulmonary C‐fibre afferents in rats
TLDR
A pronounced increase in the baseline activity and excitability of pulmonary C‐fibres is induced by intrathoracic hyperthermia, and this enhanced sensitivity probably involves activation of temperature‐sensitive ion channel(s), presumably one or more of the TRPV receptors, expressed on the C‐ fibre endings. Expand
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade
TLDR
This work reports that the abundance of tumor necrosis factor receptor-associated factor 2 and NcK-interacting kinase (TNIK), a kinase that is presumed to regulate neural plasticity, was specifically enhanced in ipsilateral dorsal horn neurons after spinal nerve ligation to suggest a potential medical treatment strategy for neuropathic pain by targeting the F-box protein. Expand
Neuropathic Allodynia Involves Spinal Neurexin-1&bgr;-dependent Neuroligin-1/Postsynaptic Density-95/NR2B Cascade in Rats
TLDR
SNL-induced allodynia, which is mediated by the spinal NL1/PSD-95/pNR2B cascade, can be prevented by blockade of transsynaptic Nrx1b–NL1 interactions. Expand
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