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Proximal Interphalangeal Joint 3

Known as: PIP3 
A ginglymoid (hinge) synovial joint within the third digit of the hand or foot connecting the proximal and middle phalanges.
National Institutes of Health

Related topics

Related topics

4 relations
Body partCDISC SDTM Anatomical Location TerminologyClinical Data Interchange Standards Consortium TerminologySkeletal system

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation
Kindlin-2 belongs to a subfamily of FERM domain containing proteins, which plays key roles in activating integrin transmembrane… 
Highly Cited
2011
Highly Cited
2011
Hydrogen Sulfide and l-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating…
Background: H2S and l-cysteine (LC) levels are low in diabetes. Results: H2S or LC inhibits PTEN and activates IRS1, PI3K, AKT… 
2007
2007
Direct Evidence for the Action of Phosphatidylinositol (3,4,5)-Trisphosphate-Mediated Signal Transduction in the 2-Cell Mouse Embryo1
Abstract Paf (1-o-alkyl-2-acetyl-sn-gylcero-3-phosphocholine) is a putative autocrine survival factor for the preimplantation… 
Highly Cited
2004
Highly Cited
2004
Centaurin-α1 Is an in Vivo Phosphatidylinositol 3,4,5-Trisphosphate-dependent GTPase-activating Protein for ARF6 That Is Involved in Actin Cytoskeleton Organization*
The ADP-ribosylation factor (ARF) 6 small GTPase regulates vesicle trafficking and cytoskeletal actin reorganization. The GTPase… 
Highly Cited
2000
Highly Cited
2000
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
Loss of the tumor suppressor MMAC1 has been shown to be involved in breast, prostate and brain cancer. Consistent with its… 
Highly Cited
1999
Highly Cited
1999
EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain.
ADP-ribosylation factors (ARFs) are small GTP-binding proteins that function as regulators of eukaryotic vesicle trafficking… 
Highly Cited
1997
Highly Cited
1997
Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate…
Phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol 3,4,5-trisphosphate (PIP3) play an essential role in the… 
Highly Cited
1996
Highly Cited
1996
Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase
The catalytic DNA primase subunit of the DNA polymerase alpha-primase complex is encoded by the essential PRI1 gene in… 
Highly Cited
1993
Highly Cited
1993
Activation of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.
Phosphatidylinositol 3-kinase (PI 3-kinase) was partially purified from rat liver cytosol and used to synthesize… 
Highly Cited
1990
Highly Cited
1990
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen
Phosphatidylinositol 3-kinase associates with the polyomavirus middle T antigen (PyMTAg)-pp60c-src complex in polyomavirus… 
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