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Protein Structure Initiative

Known as: PSI 
A NIGMS initiative to define the basic protein shapes and to catalog all proteins in terms of these shapes. This project will require the… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Making membrane proteins for structures: a trillion tiny tweaks
Researchers try multiple means to get high-quality membrane proteins for X-ray crystallography and nuclear magnetic resonance… 
Review
2010
Review
2010
Advances in protein NMR provided by the NIGMS Protein Structure Initiative: impact on drug discovery.
Rational drug design relies on the 3D structures of biological macromolecules, with a particular emphasis on proteins. The… 
2010
2010
Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism
Structures of the first representatives of PF06684 (DUF1185) reveal a Bacillus chorismate mutase-like fold with a potential role… 
2009
2009
Charting an Unknown Protein Universe
​OnOn the surface, the protein universe seems dauntingly vast. Driven by the increasingly rapid accumulation of genomic sequences… 
Review
2008
Review
2008
Protein Structure Initiative: Phase 3 or Phase Out
1610 C R E D IT S ( T O P T O B O T T O M ): N E W Y O R K S T R U C T U R A L G E N O M IX R E S E A R C H C O N S O R T IU M… 
2008
2008
Powerful fusion: PSI-BLAST and consensus sequences
Motivation: A typical PSI-BLAST search consists of iterative scanning and alignment of a large sequence database during which a… 
2007
2007
Protein structure space is much more than the sum of its folds
  • B. Honig
  • Nature Structural &Molecular Biology
  • 2007
  • Corpus ID: 6764665
VOLUME 14 NUMBER 6 JUNE 2007 NATURE STRUCTURAL & MOLECULAR BIOLOGY To the Editor: A recent editorial in Nature Structural… 
2006
2006
Inhibition of infectious human immunodeficiency virus type 1 virions via lentiviral vector encoded short antisense RNAs.
During the life cycles of most retroviruses and lentiviruses, dimerization and packaging of two copies of viral genomic RNA is… 
2006
2006
SPINE: Structural Proteomics in Europe - The best of both worlds
Division of Structural Biology, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, England, and York… 
Review
1998
Review
1998
Class‐directed structure determination: Foundation for a protein structure initiative
The recent sequencing of many complete genomes, combined with the development of methods that allow rapid structure determination… 
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