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PHENIX: a comprehensive Python-based system for macromolecular structure solution
The PHENIX software for macromolecular structure determination is described.
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PHENIX: building new software for automated crystallographic structure determination.
Structural genomics seeks to expand rapidly the number of protein structures in order to extract the maximum amount of information from genomic sequence databases. The advent of several large-scaleExpand
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Automated MAD and MIR structure solution
A fully automated procedure for solving MIR and MAD structures has been developed using a scoring scheme to convert the structure-solution process into an optimization problem.
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Maximum-likelihood density modification
  • T. Terwilliger
  • Biology, Medicine
  • Acta crystallographica. Section D, Biological…
  • 1 August 2000
A likelihood-based density modification approach is developed that can incorporate expected electron-density information from a wide variety of sources.
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Towards automated crystallographic structure refinement with phenix.refine
phenix.refine is a program within the PHENIX package that supports crystallographic structure refinement against experimental data with a wide range of upper resolution limits using a largeExpand
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Engineering and characterization of a superfolder green fluorescent protein
Existing variants of green fluorescent protein (GFP) often misfold when expressed as fusions with other proteins. We have generated a robustly folded version of GFP, called 'superfolder' GFP, thatExpand
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SOLVE and RESOLVE: automated structure solution and density modification.
SOLVE and RESOLVE have shown that it is possible to automate a significant part of the macromolecular X-ray structure determination process. The key elements of seamless and compatible subprograms,Expand
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Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein
Existing protein tagging and detection methods are powerful but have drawbacks. Split protein tags can perturb protein solubility or may not work in living cells. Green fluorescent protein (GFP)Expand
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Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard
The highly automated PHENIX AutoBuild wizard is described. The procedure can be applied equally well to phases derived from isomorphous/anomalous and molecular-replacement methods.
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Automated main-chain model building by template matching and iterative fragment extension
  • T. Terwilliger
  • Medicine, Biology
  • Acta crystallographica. Section D, Biological…
  • 20 December 2002
A method for automated macromolecular main-chain model building is described.
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