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ESPript: analysis of multiple sequence alignments in PostScript
TLDR
The program ESPript allows the rapid visualization, via PostScript output, of sequences aligned with popular programs such as CLUSTAL-W or GCG PILEUP, and can read secondary structure files to produce a synthesis of both sequence and structural information.
A mechanism for initiating RNA-dependent RNA polymerization
TLDR
The results provide a working model for the initiation of replication and transcription of double-stranded RNA viruses and flaviviruses and suggest a mechanism by which the incoming double-Stranded RNA is opened up to feed the template through to the active site, while the substrates enter by another route.
The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution
TLDR
The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information and the most immunogenic portion of the capsid forms a disordered protrusion on the virus surface.
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
TLDR
The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
TLDR
These structures provide a model for enterovirus uncoating in which the VP1 GH loop acts as an adaptor-sensor for cellular receptor attachment, converting heterologous inputs to a generic uncoated mechanism, highlighting new opportunities for therapeutic intervention.
Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate
TLDR
The results show that entry of type O FMDV into cells is a complex process and suggest that the initial contact with the cell surface is made through heparan sulfate.
The atomic structure of the bluetongue virus core
TLDR
The structure of the core particle of bluetongue virus has been determined by X-ray crystallography at a resolution approaching 3.5 Å, and the atomic structure indicates how approximately 1,000 protein components self-assemble.
Structure of a major immunogenic site on foot-and-mouth disease virus
TLDR
The crystal structure of FMDV's Arg-Gly-Asp-containing loop, located between β-strands G and H of capsid protein VP1, has become sufficiently ordered to allow us to describe an unambiguous conformation, which relates to some key biological properties of the virus.
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