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Protein Phosphatase Inhibitor

Any substance that inhibits a protein phosphatase, especially those that inhibit the serine/threonine protein phosphatases 1 and 2A, enzymes that… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.
Protein phosphatases have very recently emerged as important targets for chemical biology and medicinal chemistry research, and… 
Highly Cited
2004
Highly Cited
2004
Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A
Ionizing radiation induces autophosphorylation of the ataxia‐telangiectasia mutated (ATM) protein kinase on serine 1981; however… 
Review
2002
Review
2002
Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor.
As the first recognized member of the "okadaic acid class" of phosphatase inhibitors, the marine natural product okadaic acid is… 
Highly Cited
2001
Highly Cited
2001
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
Raf-1 activation is a complex process which involves plasma membrane recruitment, phosphorylation, protein-protein and lipid… 
Highly Cited
1994
Highly Cited
1994
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Highly Cited
1991
Highly Cited
1991
Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes.
Highly Cited
1991
Highly Cited
1991
The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells.
Highly Cited
1989
Highly Cited
1989
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
Okadaic acid is a polyether derivative of 38-carbon fatty acid1, and is implicated as the causative agent of diarrhetic shellfish… 
Highly Cited
1985
Highly Cited
1985
Activation of the pp60c‐src kinase by middle T antigen binding or by dephosphorylation.
The transforming protein of polyoma virus, middle T antigen, associates with the protein tyrosine kinase pp60c‐src, and analysis… 
Highly Cited
1984
Highly Cited
1984
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
The neurotransmitter dopamine has been demonstrated by biochemical1, histochemical2 and immunocytochemical3,4 techniques to be… 
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