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Protein Phosphatase Inhibitor

Any substance that inhibits a protein phosphatase, especially those that inhibit the serine/threonine protein phosphatases 1 and 2A, enzymes that… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Protein phosphatases have very recently emerged as important targets for chemical biology and medicinal chemistry research, and… Expand
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Highly Cited
2004
Highly Cited
2004
Ionizing radiation induces autophosphorylation of the ataxia‐telangiectasia mutated (ATM) protein kinase on serine 1981; however… Expand
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Highly Cited
2001
Highly Cited
2001
Raf-1 activation is a complex process which involves plasma membrane recruitment, phosphorylation, protein-protein and lipid… Expand
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Highly Cited
2001
Highly Cited
2001
Recent work has shown substantial alterations in NMDA receptor subunit expression, assembly, and phosphorylation in the dopamine… Expand
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Highly Cited
1999
Highly Cited
1999
Axin forms a complex with glycogen synthase kinase-3β (GSK-3β) and β-catenin and promotes GSK-3β-dependent phosphorylation of… Expand
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Highly Cited
1994
Highly Cited
1994
Treatment of cells with okadaic acid, a protein phosphatase inhibitor, leads to an insulin-resistant state without modification… Expand
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Highly Cited
1992
Highly Cited
1992
Extracellular deposition of the beta/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer… Expand
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Highly Cited
1991
Highly Cited
1991
Okadaic acid, a specific and potent inhibitor of protein phosphatases 2A and 1, was tested for its effect on the morphology of a… Expand
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Highly Cited
1989
Highly Cited
1989
Okadaic acid is a polyether derivative of 38-carbon fatty acid1, and is implicated as the causative agent of diarrhetic shellfish… Expand
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Highly Cited
1984
Highly Cited
1984
The neurotransmitter dopamine has been demonstrated by biochemical1, histochemical2 and immunocytochemical3,4 techniques to be… Expand
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