Protein Phosphatase Inhibitor

Any substance that inhibits a protein phosphatase, especially those that inhibit the serine/threonine protein phosphatases 1 and 2A, enzymes that… (More)
National Institutes of Health

Papers overview

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2006
2006
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.
Protein phosphatases have very recently emerged as important targets for chemical biology and medicinal chemistry research, and… (More)
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Highly Cited
2004
Highly Cited
2004
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Ionizing radiation induces autophosphorylation of the ataxia-telangiectasia mutated (ATM) protein kinase on serine 1981; however… (More)
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Highly Cited
2001
Highly Cited
2001
Dopamine D1 receptor-dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane.
Recent work has shown substantial alterations in NMDA receptor subunit expression, assembly, and phosphorylation in the dopamine… (More)
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Highly Cited
2001
Highly Cited
2001
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
Raf-1 activation is a complex process which involves plasma membrane recruitment, phosphorylation, protein-protein and lipid… (More)
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Highly Cited
1998
Highly Cited
1998
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
The regional selectivity and mechanisms underlying the toxicity of the serine/threonine protein phosphatase inhibitor okadaic… (More)
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Highly Cited
1992
Highly Cited
1992
Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.
Extracellular deposition of the beta/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer… (More)
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Highly Cited
1991
Highly Cited
1991
The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells.
Okadaic acid, a specific and potent inhibitor of protein phosphatases 2A and 1, was tested for its effect on the morphology of a… (More)
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1991
1991
A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.
The antibiotic, tautomycin, was found to be a potent inhibitor of protein phosphatases and equally effective for the type-1 and… (More)
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Highly Cited
1989
Highly Cited
1989
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
Okadaic acid is a polyether derivative of 38-carbon fatty acid1, and is implicated as the causative agent of diarrhetic shellfish… (More)
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Highly Cited
1984
Highly Cited
1984
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
The neurotransmitter dopamine has been demonstrated by biochemical1, histochemical2 and immunocytochemical3,4 techniques to be… (More)
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