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Protein FAN

Known as: Factor Associated with N-SMase Activation, Factor Associated with Neutral Sphingomyelinase Activation 
Protein FAN (917 aa, ~104 kDa) is encoded by the human NSMAF gene. This protein is involved in cell signaling via the TNF pathway.
National Institutes of Health

Related topics

Related topics

6 relations
CytoplasmLigand BindingNSMAF genePhospholipid Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
TNF-R1, an immune checkpoint in melanoma?
Through binding to and activation of two receptors, TNF-R1 and TNF-R2, Tumor Necrosis Factor α (TNF) modulates various biological… 
2015
2015
Factor associated with neutral sphingomyelinase activation (FAN), a member of the BEACH family of proteins, regulates lysosome size
2009
2009
FAN Stimulates TNFα-Induced Gene Expression, Leukocyte Recruitment, and Humoral Response1
Factor associated with neutral sphingomyelinase activation (FAN) is an adaptor protein that constitutively binds to TNF-R1… 
2004
2004
Tumor Necrosis Factor-α-Mediated Lysosomal Permeabilization Is FAN and Caspase 8 / Bid-Dependent
TNFα cytotoxic signaling involves lysosomal permeabilization with release of the lysosomal protease cathepsin B (ctsb) into the… 
Review
2001
Review
2001
Signaling at zero G: a comment.
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