Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation
- Belén G. Ramirez, C. Blázquez, T. G. del Pulgar, M. Guzmán, M. L. de Ceballos
- BiologyJournal of Neuroscience
- 23 February 2005
It is shown that senile plaques in AD patients express cannabinoid receptors CB1 and CB2, together with markers of microglial activation, and that CB1-positive neurons, present in high numbers in control cases, are greatly reduced in areas of microgoo activation.
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
- I. Galve-Roperh, C. Sánchez, M. Cortés, T. Pulgar, M. Izquierdo, M. Guzmán
- BiologyNature Network Boston
- 1 March 2000
It is shown that intratumoral administration of Δ9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2.
Cannabinoids: potential anticancer agents
- M. Guzmán
- BiologyNature Reviews. Cancer
- 1 October 2003
Cannabinoids — the active components of Cannabis sativa and their derivatives — exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In…
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
It is demonstrated that delta(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy and evidence is provided that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
It is shown that local administration of the selective CB(2) agonist JWH-133 at 50 microg/day to Rag-2(-/-) mice induced a considerable regression of malignant tumors generated by inoculation of C6 glioma cells, and showed that selective activation of the CB( 2) receptor signaled apoptosis via enhanced ceramide synthesis de novo.
Cannabinoid receptors as novel targets for the treatment of melanoma
Evaluated the efficacy of cannabinoid receptor agonists, a new family of potential antitumoral compounds, at skin melanoma, and found that Cannabinoid antiproliferative action on melanoma cells was due, at least in part, to cell cycle arrest at the G1‐S transition.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
It is shown that the CB(1) and theCB(2) receptor are expressed in normal skin and skin tumors of mice and humans and support a new therapeutic approach for the treatment of skin tumors.
The endocannabinoid system drives neural progenitor proliferation
It is demonstrated that progenitor cells express a functional endocannabinoid system that actively regulates cell proliferation both in vitro and in vivo, and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain.
Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A*
- S. Yamagishi, D. Edelstein, Xue-liang Du, Y. Kaneda, M. Guzmán, M. Brownlee
- BiologyJournal of Biological Chemistry
- 6 July 2001
It is found that leptin increases ROS generation in BAEC in a dose-dependent manner and that its effects are additive with those of glucose, which may play an important role in the progression of atherosclerosis in insulin-resistant obese diabetic patients.
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.
Results presented here show that cannabinoids lead to apoptosis of pancreatic tumor cells via a CB(2) receptor and de novo synthesized ceramide-dependent up-regulation of p8 and the endoplasmic reticulum stress-related genes ATF-4 and TRB3.