M. Guzmán

Publications238
h-index78
Citations18,633
Highly Influential Citations931
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Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation
TLDR
It is shown that senile plaques in AD patients express cannabinoid receptors CB1 and CB2, together with markers of microglial activation, and that CB1-positive neurons, present in high numbers in control cases, are greatly reduced in areas of microgoo activation. Expand
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
TLDR
It is shown that intratumoral administration of Δ9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Expand
Cannabinoids: potential anticancer agents
  • M. Guzmán
  • Medicine
  • Nature Reviews Cancer
  • 1 October 2003
Cannabinoids — the active components of Cannabis sativa and their derivatives — exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In… Expand
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
TLDR
It is demonstrated that delta(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy and evidence is provided that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers. Expand
Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor.
TLDR
It is shown that local administration of the selective CB(2) agonist JWH-133 at 50 microg/day to Rag-2(-/-) mice induced a considerable regression of malignant tumors generated by inoculation of C6 glioma cells, and showed that selective activation of the CB( 2) receptor signaled apoptosis via enhanced ceramide synthesis de novo. Expand
The endocannabinoid system drives neural progenitor proliferation
TLDR
It is demonstrated that progenitor cells express a functional endocannabinoid system that actively regulates cell proliferation both in vitro and in vivo, and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain. Expand
Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A*
TLDR
It is found that leptin increases ROS generation in BAEC in a dose-dependent manner and that its effects are additive with those of glucose, which may play an important role in the progression of atherosclerosis in insulin-resistant obese diabetic patients. Expand
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.
TLDR
The stress-regulated protein p8 is identified as an essential mediator of cannabinoid antitumoral action and it is shown that p8 upregulation is dependent on de novo-synthesized ceramide and mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3. Expand
Inhibition of tumor angiogenesis by cannabinoids
TLDR
It is shown that local administration of a nonpsychoactive cannabinoid to mice inhibits angiogenesis of malignant gliomas as determined by immunohistochemical analyses and vascular permeability assays. Expand
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
TLDR
It is shown that eCB signaling is operational in subcortical proliferative zones from embryonic day 12 in the mouse telencephalon and controls the proliferation of pyramidal cell progenitors and radial migration of immaturePyramidal cells. Expand
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