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Protein Cereblon

Protein cereblon (442 aa, ~51 kDa) is encoded by the human CRBN gene. This protein plays a role in assembly and regulation of calcium-activated… 
National Institutes of Health

Related topics

Related topics

6 relations
CRBN geneGenes, RegulatorProtein Complex SubunitUbiquitinated Protein Degradation

Papers overview

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2020
2020
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
2020
2020
Rationale of targeting protein cereblon as a potential strategy for cancer treatment
2017
2017
Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
The protein cereblon is part of the CRL4-CRBN E3 ubiquitin ligase complex, and has been shown to be the molecular target for the… 
2014
2014
Cereblon - nový terapeutický ciel' v liečbe mnohopočetného myelómu
Liecba mnohopocetneho myelomu (multiple myeloma - MM), v sucasnosti nevyliecitelheho ochorenia, sa zameriava na dosiahnutie… 
Highly Cited
2012
Highly Cited
2012
Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding
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