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Protein Cereblon

Protein cereblon (442 aa, ~51 kDa) is encoded by the human CRBN gene. This protein plays a role in assembly and regulation of calcium-activated… 
National Institutes of Health

Related topics

Related topics

6 relations
CRBN geneGenes, RegulatorProtein Complex SubunitUbiquitinated Protein Degradation

Papers overview

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2020
2020
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
2020
2020
Rationale of targeting protein cereblon as a potential strategy for cancer treatment
2019
2019
Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade.
2017
2017
Abstract SY37-02: Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects
The protein cereblon is part of the CRL4-CRBN E3 ubiquitin ligase complex, and has been shown to be the molecular target for the… 
2014
2014
Cereblon - nový terapeutický ciel' v liečbe mnohopočetného myelómu
Liecba mnohopocetneho myelomu (multiple myeloma - MM), v sucasnosti nevyliecitelheho ochorenia, sa zameriava na dosiahnutie… 
Highly Cited
2012
Highly Cited
2012
Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding
2011
2011
mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain
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