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CRBN gene

Known as: CRBN, CEREBLON, MRT2 
This gene plays a role in limb outgrowth and may play a role in brain development.
National Institutes of Health

Related topics

Related topics

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Protein Cereblon

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN
Immunomodulatory compounds, IMiDs® lenalidomide and pomalidomide mediate their anti-myeloma activities via cereblon, a component… 
Highly Cited
2018
Highly Cited
2018
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).
Highly Cited
2018
Highly Cited
2018
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
We present the development of the first small molecule degraders that can induce anaplastic lymphoma kinase (ALK) degradation… 
Review
2016
Review
2016
Systematic approaches to identify E3 ligase substrates
Protein ubiquitylation is a widespread post-translational modification, regulating cellular signalling with many outcomes, such… 
Highly Cited
2016
Highly Cited
2016
Novel BET protein Proteolysis Targeting Chimera (BET-PROTAC) exerts superior lethal activity than Bromodomain Inhibitor (BETi) against post-myeloproliferative Neoplasm (MPN) Secondary (s) AML Cells
The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin… 
Highly Cited
2015
Highly Cited
2015
Rate of CRL4CRBN substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4
Recent discoveries suggest that the critical events leading to the anti-proliferative activity of the IMiD immunomodulatory… 
Highly Cited
2015
Highly Cited
2015
Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets.
In preclinical studies, pomalidomide mediated both direct antitumor effects and immune activation by binding cereblon. However… 
Highly Cited
2012
Highly Cited
2012
Lenalidomide efficacy in activated B‐cell‐like subtype diffuse large B‐cell lymphoma is dependent upon IRF4 and cereblon expression
Durable responses with lenalidomide monotherapy have been reported in patients with non‐Hodgkin lymphoma. In relapsed/refractory… 
Highly Cited
2012
Highly Cited
2012
Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding
Review
2011
Review
2011
Teratogenic effects of thalidomide: molecular mechanisms
Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now… 
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