CRBN gene

Known as: CRBN, CEREBLON, MRT2 
This gene plays a role in limb outgrowth and may play a role in brain development.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
In the 1950s, the drug thalidomide, administered as a sedative to pregnant women, led to the birth of thousands of children with… (More)
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Highly Cited
2014
Highly Cited
2014
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is… (More)
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Highly Cited
2014
Highly Cited
2014
Cereblon (CRBN), the molecular target of lenalidomide and pomalidomide, is a substrate receptor of the cullin ring E3 ubiquitin… (More)
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Highly Cited
2014
Highly Cited
2014
Thalidomide-like drugs such as lenalidomide are clinically important treatments for multiple myeloma and show promise for other B… (More)
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Highly Cited
2012
Highly Cited
2012
Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The… (More)
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Highly Cited
2011
Highly Cited
2011
The precise molecular mechanism of action and targets through which thalidomide and related immunomodulatory drugs (IMiDs) exert… (More)
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Highly Cited
2010
Highly Cited
2010
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing… (More)
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Highly Cited
2008
Highly Cited
2008
Recent studies have shown that autosomal recessive mental retardation (ARMR) is extremely heterogeneous, and there is reason to… (More)
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2005
2005
Large-conductance Ca2+-activated K+ (BK(Ca)) channels are activated by membrane depolarization and modulated by intracellular Ca2… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Identifying the genetic factors that contribute to memory and learning is limited by the complexity of brain… (More)
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