Teratogenic effects of thalidomide: molecular mechanisms

@article{Ito2010TeratogenicEO,
  title={Teratogenic effects of thalidomide: molecular mechanisms},
  author={Takumi Ito and Hideki Ando and Hiroshi Handa},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={1569-1579}
}
Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use is limited due to its potent teratogenic activity. The mechanism by which thalidomide causes limb malformations and other developmental defects is a long-standing question. Multiple hypotheses exist to explain the molecular mechanism of thalidomide action. Among them, theories involving oxidative… 

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