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Prostaglandin D2

Known as: D2, Prostaglandin, F2 alpha, 11-Dehydroprostaglandin, PGD2 
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (6)

15-deoxyprostaglandin J29-deoxy-delta-9-prostaglandin D2TS-002delta(12)-prostaglandin J(2)
HPGDS geneIn BloodProcess of secretionProstaglandin Antagonists

Papers overview

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Highly Cited
2015
Highly Cited
2015
Mediator release after nasal airway challenge with allergen.
An in vivo model of human allergic disease has been developed in which nasal challenge with antigen leads to physiologic changes… 
Review
2007
Review
2007
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
Immunological activation of mast cells is an important trigger in the cascade of inflammatory events leading to the manifestation… 
Review
2001
Review
2001
Genetic and pharmacological analysis of prostanoid receptor function.
When tissues are exposed to diverse physiological and pathological stimuli, arachidonic acid is liberated from membrane… 
Highly Cited
2001
Highly Cited
2001
Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor.
Prostaglandin D2 (PGD2) is released following exposure of asthmatics to allergen and acts via the adenylyl cyclase-coupled… 
Highly Cited
1993
Highly Cited
1993
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.
Highly Cited
1993
Highly Cited
1993
Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.
Highly Cited
1985
Highly Cited
1985
Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist.
SQ 29,548, [1S-[1 alpha,2 beta (5Z),3 beta,4 alpha]-7-[3-[[2-[(phenylamino) carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1] hept-2… 
Highly Cited
1985
Highly Cited
1985
Inflammatory mediators in late antigen-induced rhinitis.
To investigate the mechanisms responsible for the late-phase response in patients with allergies, we measured four biochemical… 
Highly Cited
1984
Highly Cited
1984
The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men.
Although prostaglandin D2 is the most abundant prostanoid generated by human lung mast cells and causes bronchoconstriction in… 
Highly Cited
1980
Highly Cited
1980
Accumulation of Cyclooxygenase Products of Arachidonic Acid Metabolism in Gerbil Brain During Reperfusion After Bilateral Common Carotid Artery Occlusion
: Several of the cyclooxygenase products of arachidonic acid were measured in the cerebral hemispheres of gerbils subjected to… 
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