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Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Sepsis — which is a severe life-threatening infection with organ dysfunction — initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race… Expand
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
Failures of highly touted trials have caused experts to call for re-evaluation of the current approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy results have shown… Expand
Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony
Septic syndromes represent a major although largely underrecognized healthcare problem worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis deeply perturbs immune… Expand
The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives
The diagnosis of immediate allergy is mainly based upon an evocative clinical history, positive skin tests (gold standard) and, if available, detection of specific IgE. In some complicated cases,… Expand
Procalcitonin as an Acute Phase Marker
Procalcitonin is a 14-kDa protein encoded by the Calc-I gene along with calcitonin and katacalcin. The function and regulation of this protein are quite different from those of the other gene… Expand
Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
AbstractObjectiveThe immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The… Expand
Regulatory T cell populations in sepsis and trauma.
Sepsis syndrome remains the leading cause of mortality in intensive care units. It is now believed that along with the body's hyperinflammatory response designated to eliminate the underlying… Expand
The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration.
The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to… Expand
Marked improvement of the basophil activation test by detecting CD203c instead of CD63
- R. Boumiza, G. Monneret, +4 authors J. Bienvenu
- Clinical and experimental allergy : journal of…
- 1 February 2003
Background The flow cytometric basophil activation test by detection of CD63 expression has been developed as an alternative method for in vitro diagnosis of IgE‐mediated reactions to various… Expand
Alveolar and Serum Procalcitonin: Diagnostic and Prognostic Value in Ventilator-associated Pneumonia
- F. Duflo, R. Debon, G. Monneret, J. Bienvenu, D. Chassard, B. Allaouchiche
- 1 January 2002
Background The potential role of serum and alveolar procalcitonin as early markers of ventilator-associated pneumonia (VAP) and its prognostic value were investigated. Methods Ninety-six patients… Expand