• Publications
  • Influence
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Sepsis — which is a severe life-threatening infection with organ dysfunction — initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a raceExpand
  • 1,001
  • 47
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
Failures of highly touted trials have caused experts to call for re-evaluation of the current approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy results have shownExpand
  • 792
  • 38
Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony
Septic syndromes represent a major although largely underrecognized healthcare problem worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis deeply perturbs immuneExpand
  • 291
  • 17
The basophil activation test by flow cytometry: recent developments in clinical studies, standardization and emerging perspectives
The diagnosis of immediate allergy is mainly based upon an evocative clinical history, positive skin tests (gold standard) and, if available, detection of specific IgE. In some complicated cases,Expand
  • 133
  • 11
Procalcitonin as an Acute Phase Marker
Procalcitonin is a 14-kDa protein encoded by the Calc-I gene along with calcitonin and katacalcin. The function and regulation of this protein are quite different from those of the other geneExpand
  • 163
  • 11
Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock
AbstractObjectiveThe immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. TheExpand
  • 333
  • 10
Regulatory T cell populations in sepsis and trauma.
Sepsis syndrome remains the leading cause of mortality in intensive care units. It is now believed that along with the body's hyperinflammatory response designated to eliminate the underlyingExpand
  • 178
  • 8
The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration.
The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was toExpand
  • 192
  • 8
Marked improvement of the basophil activation test by detecting CD203c instead of CD63
Background The flow cytometric basophil activation test by detection of CD63 expression has been developed as an alternative method for in vitro diagnosis of IgE‐mediated reactions to variousExpand
  • 126
  • 8
Alveolar and Serum Procalcitonin: Diagnostic and Prognostic Value in Ventilator-associated Pneumonia
Background The potential role of serum and alveolar procalcitonin as early markers of ventilator-associated pneumonia (VAP) and its prognostic value were investigated. Methods Ninety-six patientsExpand
  • 125
  • 8