Proprotein

Known as: Propeptide 
An inactive protein precursor that is made active by cleavage or glycosylation.

Topic mentions per year

Topic mentions per year

1984-2017
05010019842017

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND LDL cholesterol (LDL-C) is a well established risk factor for cardiovascular disease. Proprotein convertase subtilisin… (More)
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Highly Cited
2009
Highly Cited
2009
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL… (More)
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Highly Cited
2008
Highly Cited
2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained attention as a key regulator of serum low density lipoprotein… (More)
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Highly Cited
2007
Highly Cited
2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of hepatic low density lipoprotein receptors (LDLR… (More)
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Highly Cited
2007
Highly Cited
2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the… (More)
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Highly Cited
2006
Highly Cited
2006
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of subtilases that reduces the… (More)
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Highly Cited
2002
Highly Cited
2002
The results of studies with cultured endothelial cells have shown that most von Willebrand factor (vWF) synthesized is directly… (More)
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Highly Cited
1999
Highly Cited
1999
Bone morphogenetic proteins (BMPs) are derived from inactive precursor proteins by endoproteolytic cleavage. Here we show that… (More)
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Highly Cited
1997
Highly Cited
1997
Furin catalyzes the proteolytic maturation of many proproteins within the trans-Golgi network (TGN)/endosomal system. Furin's… (More)
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