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The Hallmarks of Cancer
This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute. Expand
Hallmarks of Cancer: The Next Generation
Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. Expand
Studies on transformation of Escherichia coli with plasmids.
  • D. Hanahan
  • Biology, Medicine
  • Journal of molecular biology
  • 5 June 1983
Competition with both transforming and non-transforming plasmids indicates that each cell is capable of taking up many DNA molecules, and that the establishment of a transformation event is neither helped nor hindered significantly by the presence of multiple plasmid molecules. Expand
The Consensus Molecular Subtypes of Colorectal Cancer
An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features. Expand
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute. Expand
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9. Expand
Modes of resistance to anti-angiogenic therapy
Emerging data support a proposition that two modes of unconventional resistance underlieAngiogenesis inhibitors targeting the vascular endothelial growth factor signalling pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in an increasing number of human cancers. Expand
Accessories to the crime: functions of cells recruited to the tumor microenvironment.
Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types, which presents interesting new targets for anticancer therapy. Expand
Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy
Three PDA subtypes are defined: classical, quasimesenchymal and exocrine-like, and evidence for clinical outcome and therapeutic response differences between them is presented, and gene signatures for these subtypes that may have utility in stratifying patients for treatment are defined. Expand
Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.
Statistical analysis of plasmid rescue frequencies has revealed that the MDRS loci detect differential modifications of the transgene insertions among mouse lines that show distinctive patterns of transgenes expression. Expand