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Hallmarks of Cancer: The Next Generation
The Hallmarks of Cancer
Studies on transformation of Escherichia coli with plasmids.
- D. Hanahan
- BiologyJournal of molecular biology
- 5 June 1983
The Consensus Molecular Subtypes of Colorectal Cancer
An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.
Accessories to the crime: functions of cells recruited to the tumor microenvironment.
Modes of resistance to anti-angiogenic therapy
Emerging data support a proposition that two modes of unconventional resistance underlieAngiogenesis inhibitors targeting the vascular endothelial growth factor signalling pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in an increasing number of human cancers.
Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy
Three PDA subtypes are defined: classical, quasimesenchymal and exocrine-like, and evidence for clinical outcome and therapeutic response differences between them is presented, and gene signatures for these subtypes that may have utility in stratifying patients for treatment are defined.
Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.
- S. Grant, J. Jessee, F. Bloom, D. Hanahan
- BiologyProceedings of the National Academy of Sciences…
- 1 June 1990
Statistical analysis of plasmid rescue frequencies has revealed that the MDRS loci detect differential modifications of the transgene insertions among mouse lines that show distinctive patterns of transgenes expression.