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Proprotein Convertase 5

Known as: Prohormone Convertase PC 6, Proprotein Convertase, PC5, PC5 Protein 
A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN… 
National Institutes of Health

Related topics

Related topics

12 relations
In BloodPCSK5 geneProcess of secretionantagonists & inhibitors

Narrower (3)

PC5B Preprotein Convertasepropeptide convertase 5, mousepropeptide convertase 5, rat

Broader (1)

Serine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2019 EXECUTIVE SUMMARY.
ABBREVIATIONS A1C = hemoglobin A1C; AACE = American Association of Clinical Endocrinologists; ACCORD = Action to Control… 
Highly Cited
2013
Highly Cited
2013
Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation*
Background: Secreted PCSK9 regulates LDL levels in plasma by mediating degradation of hepatic LDL receptors. Results: LDL binds… 
Highly Cited
2010
Highly Cited
2010
Angiopoietin-like Protein 3 Inhibits Lipoprotein Lipase Activity through Enhancing Its Cleavage by Proprotein Convertases*
Lipoprotein lipase (LPL)-mediated lipolysis of triglycerides is the first and rate-limiting step in chylomicron/very low density… 
Highly Cited
2007
Highly Cited
2007
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice Published, JLR Papers in Press, January 22, 2007.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the… 
Highly Cited
2006
Highly Cited
2006
On the Processing of Proghrelin to Ghrelin*
The orexigenic hormone ghrelin is a 28-amino-acid peptide derived from a 99-amino-acid precursor and acylated at Ser-3, which was… 
Highly Cited
2000
Highly Cited
2000
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.
Membrane type-1 matrix metalloproteinase (MT1-MMP) is the prototypical member of a subgroup of membrane-anchored proteinases that… 
Highly Cited
1995
Highly Cited
1995
Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide (*)
Proglucagon is processed differently in the islet α cells and the intestinal endocrine L cells to release either glucagon or… 
Highly Cited
1991
Highly Cited
1991
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary…
Using a 796-basepair cDNA fragment obtained from a mouse pituitary library we have screened two mouse insulinoma libraries and… 
Highly Cited
1991
Highly Cited
1991
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
PC2 and furin are two recently identified members of a class of mammalian proteins homologous to the yeast precursor processing… 
Highly Cited
1989
Highly Cited
1989
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
The KEX2-encoded endoprotease was overproduced in yeast several hundred-fold and further purified to achieve a 10,000-fold… 
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