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Proprotein Convertase 5
Known as:
Prohormone Convertase PC 6
, Proprotein Convertase, PC5
, PC5 Protein
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A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN…
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National Institutes of Health
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Related topics
Related topics
12 relations
In Blood
PCSK5 gene
Process of secretion
antagonists & inhibitors
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Narrower (3)
PC5B Preprotein Convertase
propeptide convertase 5, mouse
propeptide convertase 5, rat
Broader (1)
Serine Endopeptidases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network.
Tiebang Kang
,
H. Nagase
,
D. Pei
Cancer Research
2002
Corpus ID: 7800497
Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases implicated in tumor invasion and metastasis, must…
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Highly Cited
2001
Highly Cited
2001
Impaired Prohormone Convertases inCpe fat/Cpe fat Mice*
Y. Berman
,
N. Mzhavia
,
A. Polonskaia
,
L. Devi
Journal of Biological Chemistry
2001
Corpus ID: 42973646
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that…
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Highly Cited
1999
Highly Cited
1999
Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
H. Furukawa
,
R. Carroll
,
H. Swift
,
D. Steiner
Diabetes
1999
Corpus ID: 30553753
To explore the role of chronically elevated free fatty acids (FFAs) in the pathogenesis of the hyperproinsulinemia of type 2…
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Highly Cited
1997
Highly Cited
1997
Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.
N. Brakch
,
B. Rist
,
+5 authors
Eric Grouzmann
Biochemistry
1997
Corpus ID: 2147739
Proneuropeptide Y (ProNPY) undergoes cleavage at a single dibasic site Lys38-Arg39 resulting in the formation of 1-39 amino acid…
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Highly Cited
1997
Highly Cited
1997
β-Cell Lines Derived from Transgenic Cpefat/Cpefat Mice Are Defective in Carboxypeptidase E and Proinsulin Processing.
O. Varlamov
,
L. Fricker
,
H. Furukawa
,
D. Steiner
,
S. Langley
,
E. Leiter
Endocrinology
1997
Corpus ID: 1732737
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene in Cpe(fat)/Cpe(fat) mice affects…
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Highly Cited
1996
Highly Cited
1996
Identification of a Transferable Sorting Domain for the Regulated Pathway in the Prohormone Convertase PC2*
J. Creemers
,
E. Usac
,
+4 authors
J. Hutton
Journal of Biological Chemistry
1996
Corpus ID: 39102692
The mammalian subtilisin-like endoproteases furin and PC2 catalyze similar reactions but in different parts of the cell: furin in…
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Highly Cited
1995
Highly Cited
1995
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
N. Brakch
,
A. Galanopoulou
,
Y. C. Patel
,
Guy Boileau
,
N. G. Seidah
FEBS Letters
1995
Corpus ID: 42244962
Highly Cited
1995
Highly Cited
1995
Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment.
I. Lindberg
,
W. H. van den Hurk
,
C. Bui
,
C. Batie
Biochemistry
1995
Corpus ID: 13328202
Prohormone convertase (PCs) are thought to mediate the controlled proteolysis of prohormones and neuropeptide precursors. While…
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Highly Cited
1994
Highly Cited
1994
Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
M. Marcinkiewicz
,
D. Ramla
,
N. Seidah
,
M. Chrétien
Endocrinology
1994
Corpus ID: 22695211
The immunocytochemical distribution and messenger RNA expression of the prohormone convertases PC1 and PC2 involved in the…
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Highly Cited
1993
Highly Cited
1993
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.
F. Jean
,
A. Basak
,
+5 authors
C. Lazure
Biochemical Journal
1993
Corpus ID: 25627408
Prohormone convertase-1 (PC1), an endopeptidase that is structurally related to the yeast subtilisin-like Kex2 gene product, has…
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