Proprotein Convertase 5

Known as: Prohormone Convertase PC 6, Proprotein Convertase, PC5, PC5 Protein 
A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Despite statin treatment, many patients with heterozygous familial hypercholesterolemia do not reach desired low… (More)
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Highly Cited
2008
Highly Cited
2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained attention as a key regulator of serum low density lipoprotein… (More)
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Highly Cited
2008
Highly Cited
2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilases that promotes the internalization and… (More)
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Highly Cited
2007
Highly Cited
2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart… (More)
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Highly Cited
2000
Highly Cited
2000
Membrane type-1 matrix metalloproteinase (MT1-MMP) is the prototypical member of a subgroup of membrane-anchored proteinases that… (More)
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Review
1999
Review
1999
Proproteins and prohormones are the fundamental units from which bioactive proteins and peptides as well as neuropeptides are… (More)
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Highly Cited
1999
Highly Cited
1999
Bone morphogenetic proteins (BMPs) are derived from inactive precursor proteins by endoproteolytic cleavage. Here we show that… (More)
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Highly Cited
1997
Highly Cited
1997
Human obesity has an inherited component, but in contrast to rodent obesity, precise genetic defects have yet to be defined1. A… (More)
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Highly Cited
1991
Highly Cited
1991
A recombinant vaccinia virus vector was used to coexpress the two candidate mouse prohormone convertases, PC1 and PC2, together… (More)
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