Proprotein Convertase 5

Known as: Prohormone Convertase PC 6, Proprotein Convertase, PC5, PC5 Protein 
A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN… (More)
National Institutes of Health

Related topics

Related topics

12 relations
In BloodPCSK5 geneProcess of secretionantagonists & inhibitors
(More)

Narrower (3)

PC5B Preprotein Convertasepropeptide convertase 5, mousepropeptide convertase 5, rat

Broader (1)

Serine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial…
BACKGROUND Despite statin treatment, many patients with heterozygous familial hypercholesterolemia do not reach desired low… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained attention as a key regulator of serum low density lipoprotein… (More)
  • figure 1
  • figure 3
  • figure 2
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilases that promotes the internalization and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.
BACKGROUND A low plasma level of low-density lipoprotein (LDL) cholesterol is associated with reduced risk of coronary heart… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.
Membrane type-1 matrix metalloproteinase (MT1-MMP) is the prototypical member of a subgroup of membrane-anchored proteinases that… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
1999
Review
1999
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
Proproteins and prohormones are the fundamental units from which bioactive proteins and peptides as well as neuropeptides are… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases
Bone morphogenetic proteins (BMPs) are derived from inactive precursor proteins by endoproteolytic cleavage. Here we show that… (More)
  • table I
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
Human obesity has an inherited component, but in contrast to rodent obesity, precise genetic defects have yet to be defined1. A… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
A recombinant vaccinia virus vector was used to coexpress the two candidate mouse prohormone convertases, PC1 and PC2, together… (More)
Is this relevant?