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Proprotein Convertase 5

Known as: Prohormone Convertase PC 6, Proprotein Convertase, PC5, PC5 Protein 
A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage of a variety of substrates including PRORENIN… 
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases implicated in tumor invasion and metastasis, must… 
Highly Cited
2001
Highly Cited
2001
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that… 
Highly Cited
1999
Highly Cited
1999
To explore the role of chronically elevated free fatty acids (FFAs) in the pathogenesis of the hyperproinsulinemia of type 2… 
Highly Cited
1997
Highly Cited
1997
Proneuropeptide Y (ProNPY) undergoes cleavage at a single dibasic site Lys38-Arg39 resulting in the formation of 1-39 amino acid… 
Highly Cited
1997
Highly Cited
1997
A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene in Cpe(fat)/Cpe(fat) mice affects… 
Highly Cited
1996
Highly Cited
1996
The mammalian subtilisin-like endoproteases furin and PC2 catalyze similar reactions but in different parts of the cell: furin in… 
Highly Cited
1995
Highly Cited
1995
Prohormone convertase (PCs) are thought to mediate the controlled proteolysis of prohormones and neuropeptide precursors. While… 
Highly Cited
1994
Highly Cited
1994
The immunocytochemical distribution and messenger RNA expression of the prohormone convertases PC1 and PC2 involved in the… 
Highly Cited
1993
Highly Cited
1993
Prohormone convertase-1 (PC1), an endopeptidase that is structurally related to the yeast subtilisin-like Kex2 gene product, has…