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Proneural Glioblastoma

A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa… Expand
National Institutes of Health

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AnaplasiaAstrocytesCentral Nervous SystemGrade four rank
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Papers overview

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2017
2017
Angiogenic Gene Signature Derived from Subtype Specific Cell Models Segregate Proneural and Mesenchymal Glioblastoma
Intertumoral molecular heterogeneity in glioblastoma identifies four major subtypes based on expression of molecular markers… Expand
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2016
2016
Optimization of radiation dosing schedules for proneural glioblastoma
Glioblastomas are the most aggressive primary brain tumor. Despite treatment with surgery, radiation and chemotherapy, these… Expand
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2014
2014
The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression.
Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a… Expand
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2014
2014
Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.
BACKGROUND Glioblastoma subtypes have been defined based on transcriptional profiling, yet personalized care based on molecular… Expand
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2012
2012
The cancer stem cell subtype determines immune infiltration of glioblastoma.
Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown… Expand
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2012
2012
NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.
Proneural NEUROG2 (neurogenin 2 [Ngn2]) is essential for neuronal commitment, cell cycle withdrawal, and neuronal differentiation… Expand
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Highly Cited
2012
Highly Cited
2012
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.
Growth factor-mediated proliferation and self-renewal maintain tissue-specific stem cells and are frequently dysregulated in… Expand
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2010
2010
Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival.
Patients with glioblastoma (GBM) have variable clinical courses, but the factors that underlie this heterogeneity are not… Expand
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Highly Cited
2009
Highly Cited
2009
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and… Expand
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1998
1998
Regulation of Drosophila Neurogenesis byRNA:RNA Duplexes?
1997). The novel non-bHLH protein encoded by the m4 Neurogenesis by gene of the E(spl)-C (Klä mbt et al., 1989), which is… Expand
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