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Proneural Glioblastoma

A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa… Expand
National Institutes of Health

Related topics

Related topics

17 relations
AnaplasiaAstrocytesCentral Nervous SystemGrade four rank
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The phenotypes of proliferating glioblastoma cells reside on a single axis of variation.
Although tumor-propagating cells can be derived from glioblastomas (GBMs) of the proneural and mesenchymal subtypes, a glioma… Expand
2016
2016
Optimization of radiation dosing schedules for proneural glioblastoma
Glioblastomas are the most aggressive primary brain tumor. Despite treatment with surgery, radiation and chemotherapy, these… Expand
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Highly Cited
2015
Highly Cited
2015
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
PURPOSE The AVAglio (Avastin in Glioblastoma) and RTOG-0825 randomized, placebo-controlled phase III trials in newly diagnosed… Expand
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Highly Cited
2015
Highly Cited
2015
STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.
High grade gliomas (HGG) are classified into four subgroups based on transcriptional signatures and phenotypic characteristics… Expand
Highly Cited
2012
Highly Cited
2012
The cancer stem cell subtype determines immune infiltration of glioblastoma.
Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown… Expand
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Highly Cited
2012
Highly Cited
2012
NEUROG2 Drives Cell Cycle Exit of Neuronal Precursors by Specifically Repressing a Subset of Cyclins Acting at the G1 and S Phases of the Cell Cycle
ABSTRACT Proneural NEUROG2 (neurogenin 2 [Ngn2]) is essential for neuronal commitment, cell cycle withdrawal, and neuronal… Expand
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Highly Cited
2012
Highly Cited
2012
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.
Growth factor-mediated proliferation and self-renewal maintain tissue-specific stem cells and are frequently dysregulated in… Expand
Highly Cited
2010
Highly Cited
2010
Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival
Patients with glioblastoma (GBM) have variable clinical courses, but the factors that underlie this heterogeneity are not… Expand
Highly Cited
2009
Highly Cited
2009
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and… Expand
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1998
1998
Regulation of Drosophila Neurogenesis byRNA:RNA Duplexes?
1997). The novel non-bHLH protein encoded by the m4 Neurogenesis by gene of the E(spl)-C (Klä mbt et al., 1989), which is… Expand
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