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Proneural Glioblastoma

A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa… 
National Institutes of Health

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17 relations
AnaplasiaAstrocytesCentral Nervous SystemGrade four rank

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma
Background Mouse models of glioblastoma (GBM), the most aggressive primary brain tumor, are critical for understanding GBM… 
2017
2017
Angiogenic Gene Signature Derived from Subtype Specific Cell Models Segregate Proneural and Mesenchymal Glioblastoma
Intertumoral molecular heterogeneity in glioblastoma identifies four major subtypes based on expression of molecular markers… 
2016
2016
Metabolic challenge of proneural glioblastoma cancer stem cell lines does not induce a mesenchymal transformation in vitro
The histologically defined tumor entity glioblastoma (GBM) comprises different molecular subgroups. On a transcriptional level… 
2015
2015
Optimization of radiation dosing schedules for proneural glioblastoma
Glioblastomas are the most aggressive primary brain tumor. Despite treatment with surgery, radiation and chemotherapy, these… 
2014
2014
Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.
BACKGROUND Glioblastoma subtypes have been defined based on transcriptional profiling, yet personalized care based on molecular… 
2014
2014
The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression.
Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a… 
Highly Cited
2012
Highly Cited
2012
NEUROG2 Drives Cell Cycle Exit of Neuronal Precursors by Specifically Repressing a Subset of Cyclins Acting at the G1 and S Phases of the Cell Cycle
ABSTRACT Proneural NEUROG2 (neurogenin 2 [Ngn2]) is essential for neuronal commitment, cell cycle withdrawal, and neuronal… 
Highly Cited
2010
Highly Cited
2010
Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival
Patients with glioblastoma (GBM) have variable clinical courses, but the factors that underlie this heterogeneity are not… 
Highly Cited
2009
Highly Cited
2009
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and… 
1998
1998
Regulation of Drosophila Neurogenesis byRNA:RNA Duplexes?
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