Prolyl Hydroxylase

Known as: Proline Hydroxylase, Hydroxylases, Prolyl, Prolyl Hydroxylases 
Enzymes that specifically hydroxylate PROLINE residues on proteins.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1973-2018
051019732018

Papers overview

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2014
2014
Arsenic exposure has been shown to induce hypoxia inducible factor 1α (HIF-1α) accumulation, however the underlying mechanism… (More)
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2012
2012
BACKGROUND Chronic hypoxia in the kidney has been suggested as a final common pathway in the progression of chronic kidney… (More)
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2011
2011
Oxygen homeostasis is crucial for development, survival and normal function of all metazoans. A family of transcription factors… (More)
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Highly Cited
2011
Highly Cited
2011
Oxygen-dependent regulation of the transcription factor HIF-1α relies on a family of prolyl hydroxylases (PHDs) that hydroxylate… (More)
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2009
2009
Hypoxia-inducible transcription factors (HIFs) play important roles in the response of the kidney to systemic and regional… (More)
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2009
2009
Cells exposed to low-oxygen conditions (hypoxia) alter their metabolism to survive. This response, although vital during… (More)
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Highly Cited
2006
Highly Cited
2006
Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NF B is activated in hypoxia, an event… (More)
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Highly Cited
2006
Highly Cited
2006
Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular adaptation… (More)
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2005
2005
The activity of hypoxia-inducible factor 1 (HIF-1) is primarily determined by stability regulation of its alpha subunit, which is… (More)
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2004
2004
The vasodilator hydralazine, used clinically in cardiovascular therapy, relaxes arterial smooth muscle by inhibiting accumulation… (More)
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