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Acute renal failure (ARF) secondary to ischemic injury remains a common and potentially devastating problem. A transcriptome-wide… Expand H2AX, a member of the histone H2A family, is rapidly phosphorylated in response to ionizing radiation. This phosphorylation, at… Expand Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we… Expand Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2… Expand The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading… Expand In cancer patients, dormant micrometastases are often asymptomatic and clinically undetectable, for months or years, until… Expand GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53… Expand Identification of the cellular proteins whose expression is regulated during the cell cycle in normal cells is essential for… Expand The mechanism of replication of the simian virus 40 (SV40) genome closely resembles that of cellular chromosomes, thereby… Expand Pulse-chase experiments have revealed that cyclin, the auxiliary protein of DNA polymerase-delta, is stable during the transition… Expand