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Comprehensive molecular portraits of human breast tumors
TLDR
The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.
Genetic alterations in lobular breast cancer by comparative genomic hybridization
TLDR
The data suggest that the altered growth pattern and clinical presentation which characterize infiltrating lobular cancers are correlated with distinct genetic alterations.
Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
TLDR
Analysis of patient and tumor characteristics revealed that certain mutation subtypes were significantly associated with Fuhrman nuclear grade, metastasis, node positivity, and self-reported family history of RCC, indicating that VHL molecular subtypes can provide a sensitive marker of tumor heterogeneity among histologically similar ccRCC cases for etiologic, prognostic, and translational studies.
High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.
TLDR
This high-resolution analysis of DNA copy number alterations in colorectal cancer by array-based CGH allowed for the identification of many small, previously uncharacterized, genomic regions, such as on chromosomes 8 and 20.
Breast tumor copy number aberration phenotypes and genomic instability
TLDR
Many of the genes associated with higher frequency of copy number aberrations are direct targets of E2F, supporting the hypothesis that deregulation of the Rb pathway is a major contributor to chromosomal instability in breast tumors.
Genetic and Phenotypic Characteristics of Pleomorphic Lobular Carcinoma In Situ of the Breast
TLDR
Although lack of E-cadherin expression and the 16q loss and 1q gain-array-based comparative genomic hybridization pattern support a relationship to CLCIS, PLCIS has clinical, mammographic, histologic, immunophenotypic, and genetic features that distinguish it from C LCIS.
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.
TLDR
Quantitative analysis of ERBB2 amplification by FISH may improve prognostic assessments based on the pattern of amplification and detection of heavily amplified tumor cell subpopulations.
Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples.
TLDR
An improved CGH technique is described, which enables reliable detection of copy number changes in archival formalin-fixed paraffin-embedded tumor samples and has wide applicability in tumor pathology, allowing large retrospective prognostic studies of genetic aberrations as well as studies on genetic pathogenesis of solid tumors.
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