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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise theExpand
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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying associations between recurrent CNAs, gene expression, and clinical outcome inExpand
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Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
Comparative genomic hybridization (CGH) is a powerful new method for molecular cytogenetic analysis of cancer. In a single hybridization, CGH provides an overview of DNA sequence copy number changesExpand
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Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.
Comparative genomic hybridization was applied to 5 breast cancer cell lines and 33 primary tumors to discover and map regions of the genome with increased DNA-sequence copy-number. Two-thirds ofExpand
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Comprehensive molecular portraits of human breast tumors
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability toExpand
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Genetic alterations in lobular breast cancer by comparative genomic hybridization
Infiltrating lobular carcinoma (ILC) and infiltrating ductal carcinoma (IDC) are distinguished by their histopathological appearance. However, little is known about the differences in genetic changesExpand
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High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.
Array-based comparative genomic hybridization (CGH) allows for the simultaneous examination of thousands of genomic loci at 1-2 Mb resolution. Copy number alterations detected by array-based CGH canExpand
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Breast tumor copy number aberration phenotypes and genomic instability
BackgroundGenomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomicExpand
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Genetic and Phenotypic Characteristics of Pleomorphic Lobular Carcinoma In Situ of the Breast
The clinical, pathologic, and molecular features of pleomorphic lobular carcinoma in situ (PLCIS) and the relationship of PLCIS to classic LCIS (CLCIS) are poorly defined. In this study, we analyzedExpand
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Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors
Purpose: To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to clear cell renal cancerExpand
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