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- Publications
- Influence
Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
- W. Choi, S. Porten, +17 authors D. McConkey
- Biology, Medicine
- Cancer cell
- 10 February 2014
Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely variable clinical outcomes and responses to conventional chemotherapy. We discovered three molecular subtypes of… Expand
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated… Expand
Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.
MicroRNAs (miRNA) are small noncoding RNA molecules involved in a diversity of cellular functions. Although it has been reported that global suppression of the miRNA biogenesis pathway leads to… Expand
Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
- D. McConkey, W. Choi, +9 authors C. Dinney
- Biology, Medicine
- Cancer and Metastasis Reviews
- 14 December 2009
Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increased… Expand
Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma.
- D. Levy, J. Slaton, D. Swanson, C. Dinney
- Medicine
- The Journal of urology
- 1 April 1998
PURPOSE
We report stage specific followup guidelines based on our evaluation of the pattern of recurrence in 286 patients treated for local N0 or Nx renal cell carcinoma.
MATERIALS AND METHODS
We… Expand
Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus.
- J. Nesbitt, E. Soltero, +6 authors J. Putnam
- Medicine
- The Annals of thoracic surgery
- 1 June 1997
BACKGROUND
The optimal management of patients with renal cell carcinoma with inferior vena cava tumor thrombus remains unresolved. Traditional approaches have included resection with or without the… Expand
Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer
- W. Choi, B. Czerniak, +4 authors D. McConkey
- Medicine
- Nature Reviews Urology
- 1 July 2014
Whole-genome analyses have revealed that muscle-invasive bladder cancers (MIBCs) are heterogeneous and can be grouped into basal and luminal subtypes that are highly reminiscent of those found in… Expand
Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: an international multicenter study.
- J. Patard, H. Kim, +18 authors A. Belldegrun
- Medicine
- Journal of clinical oncology : official journal…
- 15 August 2004
PURPOSE
To evaluate ability of the University of California Los Angeles Integrated Staging System (UISS) to stratify patients with localized and metastatic renal cell carcinoma (RCC) into risk groups… Expand
Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival.
- D. Leibovici, H. Grossman, +6 authors X. Wu
- Medicine
- Journal of clinical oncology : official journal…
- 20 August 2005
PURPOSE
Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammation… Expand
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
- P. Perrotte, T. Matsumoto, +5 authors C. Dinney
- Medicine
- Clinical cancer research : an official journal of…
- 1 February 1999
Epidermal growth factor receptor (EGFR) regulates the growth and progression of human transitional cell carcinoma (TCC) of the bladder. We have shown that therapy targeting EGFR inhibited the growth… Expand
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