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Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely variable clinical outcomes and responses to conventional chemotherapy. We discovered three molecular subtypes ofExpand
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Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validatedExpand
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Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.
MicroRNAs (miRNA) are small noncoding RNA molecules involved in a diversity of cellular functions. Although it has been reported that global suppression of the miRNA biogenesis pathway leads toExpand
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Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
Epithelial-to-mesenchymal transition (EMT) is a process that plays essential roles in development and wound healing that is characterized by loss of homotypic adhesion and cell polarity and increasedExpand
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Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma.
PURPOSE We report stage specific followup guidelines based on our evaluation of the pattern of recurrence in 286 patients treated for local N0 or Nx renal cell carcinoma. MATERIALS AND METHODS WeExpand
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Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus.
BACKGROUND The optimal management of patients with renal cell carcinoma with inferior vena cava tumor thrombus remains unresolved. Traditional approaches have included resection with or without theExpand
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Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer
Whole-genome analyses have revealed that muscle-invasive bladder cancers (MIBCs) are heterogeneous and can be grouped into basal and luminal subtypes that are highly reminiscent of those found inExpand
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Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: an international multicenter study.
PURPOSE To evaluate ability of the University of California Los Angeles Integrated Staging System (UISS) to stratify patients with localized and metastatic renal cell carcinoma (RCC) into risk groupsExpand
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Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival.
PURPOSE Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammationExpand
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Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
Epidermal growth factor receptor (EGFR) regulates the growth and progression of human transitional cell carcinoma (TCC) of the bladder. We have shown that therapy targeting EGFR inhibited the growthExpand
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