Probucol

Known as: Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole, 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol), Probucol [Chemical/Ingredient] 
A bis-phenol antioxidant with antilipidemic activity. Probucol inhibits oxidation of low density lipoprotein and lowers the level of cholesterol in… (More)
National Institutes of Health

Related topics

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28 relations

Broader (2)

Anticholesteremic AgentsAntioxidants
Antilipemic agentCoronary Artery DiseaseDrug AllergyGall Bladder Diseases
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Narrower (11)

BiphenabidCGP 2881DH-581Lesterol
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Papers overview

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Highly Cited
2002
Highly Cited
2002
Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST).
OBJECTIVES This study investigated the effect of reducing serum lipids on carotid artery intima-media thickness (IMT) in… (More)
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Highly Cited
2000
Highly Cited
2000
Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol.
BACKGROUND The clinical usefulness of adriamycin is restricted by the development of congestive heart failure. It has been… (More)
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Highly Cited
1997
Highly Cited
1997
Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group.
BACKGROUND Oxidizing metabolites generated at the site of coronary angioplasty can induce chain reactions that may lead to… (More)
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Highly Cited
1995
Highly Cited
1995
Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect.
BACKGROUND The usefulness of adriamycin (ADR), a potent antitumor antibiotic, is limited by the development of life-threatening… (More)
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Highly Cited
1995
Highly Cited
1995
The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion.
BACKGROUND Patients with coronary artery disease and abnormalities of serum lipids often have endothelial vasodilator dysfunction… (More)
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Highly Cited
1994
Highly Cited
1994
Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats.
BACKGROUND The potential usefulness of adriamycin (ADR) is restricted because of its cardiotoxic side effects. Since free… (More)
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Highly Cited
1991
Highly Cited
1991
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by…
Incubation of cocultures of human aortic endothelial (HAEC) and smooth muscle cells (HASMC) with LDL in the presence of 5-10… (More)
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Highly Cited
1987
Highly Cited
1987
Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty…
It has been postulated that low density lipoprotein (LDL) becomes fully atherogenic only if it first undergoes oxidative… (More)
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Highly Cited
1987
Highly Cited
1987
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.
In this study, we questioned whether in vivo probucol could prevent the progression of atherosclerosis in homozygous Watanabe… (More)
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Highly Cited
1986
Highly Cited
1986
Probucol inhibits oxidative modification of low density lipoprotein.
Previous studies have established that low density lipoprotein (LDL) incubated with endothelial cells (EC) undergoes extensive… (More)
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