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Probucol

Known as: Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole, 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol), Probucol [Chemical/Ingredient] 
A bis-phenol antioxidant with antilipidemic activity. Probucol inhibits oxidation of low density lipoprotein and lowers the level of cholesterol in… 
National Institutes of Health

Related topics

Related topics

28 relations

Broader (2)

Anticholesteremic AgentsAntioxidants
Antilipemic agentCoronary Artery DiseaseDrug AllergyGall Bladder Diseases

Narrower (11)

BiphenabidCGP 2881DH-581Lesterol

Papers overview

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1998
1998
Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells by reducing P-selectin synthesis in vitro.
Probucol (PBC) is an unique antiatherogenic drug producing its effect by antioxidant action rather than hypolipidaemic effect… 
Review
1982
Review
1982
Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis.
Colestipol is a safe, effective, cholesterol-lowering, bile-acid sequestrant that lowers low-density-lipoprotein (LDL) and total… 
1982
1982
Safety and effectiveness of probucol as a cholesterol lowering agent.
Monitored clinical studies conducted in 1133 patients, involving 3928 patient years of experience with probucol, have shown that… 
1982
1982
Effect of probucol on reproductive performance, egg yolk cholesterol content, and lipid metabolism in the laying hen.
Egg production type chickens were given the drug Probucol in their diets to determine its effect on egg production… 
1980
1980
Effects of Clofibrate, Cholestyramine, Zanchol, Probucol, and AOMA Feeding on Hepatic and Intestinal Cholesterol Metabolism and on Biliary Lipid Secretion in the Rat
Summary Utilizing newer techniques for measuring rates of cholesterol synthesis, the effects of clofibrate, cholestyramine… 
1980
1980
Usefulness of probucol in treating primary hypercholesterolemia.
Probucol (1 g per day) was administered in a double-blind crossover trial to 16 patients with familial hypercholesterolemia who… 
1980
1980
[Plasma levels of probucol in man after single and repeated oral doses (author's transl)].
Following administration of a single oral dose of 3 g probucol to healthy volunteers, mean peak plasma concentrations of 3.9… 
1979
1979
Effects of Probucol on Hyperlipidemic Patients with Cardiac Allografts
Probucol, a well-tolerated new drug with moderate hypocholesterolemic effect in the general population, was evaluated in… 
1975
1975
Treatment of severe and mild hypercholesterolaemia with probucol and neomycin.
Administration of probucol to 23 patients with familial xanthomatotic hypercholesterolaemia reduced the serum cholesterol level… 
1973
1973
Probucol in the long-term treatment of hypercholesterolaemia.
SummaryA new hypocholesterolaemic drug, probucol, was effective in reducing mean serum cholesterol level in 52 patients by 17…