Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels.
- M. Katan, S. Grundy, P. Jones, M. Law, T. Miettinen, R. Paoletti
- BiologyMayo Clinic proceedings
- 1 August 2003
Present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease.
Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population.
- T. Miettinen, P. Puska, H. Gylling, H. Vanhanen, E. Vartiainen
- Medicine, BiologyNew England Journal of Medicine
- 16 November 1995
BACKGROUND
Dietary plant sterols, especially sitostanol, reduce serum cholesterol by inhibiting cholesterol absorption. Soluble sitostanol may be more effective than a less soluble preparation. We…
Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population.
- T. Miettinen, R. Tilvis, Y. Kesäniemi
- MedicineAmerican Journal of Epidemiology
- 1990
The serum non-cholesterol sterols are significant indicators of cholesterol absorption and synthesis even under basal conditions and, since gas liquid chromatographic determination of these sterols is quite simple, their measurement may be valuable for monitoring cholesterol metabolism in large-scale epidemiologic studies.
Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol.
- H. Gylling, R. Radhakrishnan, T. Miettinen
- MedicineCirculation
- 16 December 1997
Dietary use of sitostanol ester margarine normalizes LDL cholesterol in about one third of women with previous myocardial infarction, especially in those with high baseline absorption and low synthesis of cholesterol, and in combination with statins reduces the needed drug dose.
Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering.
- T. Pedersen, L. Wilhelmsen, H. Wedel
- MedicineAmerican Journal of Cardiology
- 1 August 2000
Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study.
- T. Pedersen, K. Berg, L. Wilhelmsen
- MedicineArchives of Internal Medicine
- 14 October 1996
The safety profile of simvastatin, 20 to 40 mg daily, over 5 years was excellent, and the frequency of adverse events related to the central nervous system was similar in both groups.
Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels.
- T. Miettinen, Y. Kesäniemi
- MedicineAmerican Journal of Clinical Nutrition
- 1 April 1989
Cholesterol absorption efficiency and absorbed dietary cholesterol significantly regulate cholesterol synthesis and elimination and are important determinants of within-population variation in the serum levels of total, LDL, and HDL cholesterol.
QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL FECAL BILE ACIDS.
- S. Grundy, E. H. Ahrens, T. Miettinen
- BiologyJournal of Lipid Research
- 1 July 1965
This experiment indicated the stability of bile acid structure during intestinal transit and provided additional evidence for the completeness of the described method of determining fecal bile acids.
Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S)
- T. Pedersen, A. Olsson, T. Cook
- MedicineCirculation
- 21 April 1998
The analyses suggest that the beneficial effect of simvastatin in individual patients in 4S was determined mainly by the magnitude of the change in LDL cholesterol, and they are consistent with current guidelines that emphasize aggressive reduction of this lipid in CHD patients.
Gas-liquid chromatographic determination of fecal neutral sterols using a capillary column.
- T. Miettinen
- ChemistryClinica chimica acta; international journal of…
- 15 September 1982
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