Pro-Opiomelanocortin, human

Known as: POMC, Pro-Opiomelanocortin, Proopiomelanocortin 
Pro-opiomelanocortin (267 aa, ~29 kDa) is encoded by the human POMC gene. This protein plays a role in peptide hormone-dependent signaling.
National Institutes of Health

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6 relations
Adipocytokine Signaling PathwayDesire for foodIntercellular Communication ProcessPOMC gene
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Pro-Opiomelanocortin

Papers overview

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Highly Cited
2013
Highly Cited
2013
Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.
Energy and glucose homeostasis are regulated by central serotonin 2C receptors. These receptors are attractive pharmacological… (More)
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Highly Cited
2010
Highly Cited
2010
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
Circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the… (More)
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Highly Cited
2009
Highly Cited
2009
Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway.
The hypothalamic paraventricular nucleus (PVN) functions as a center to integrate various neuronal activities for regulating… (More)
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Highly Cited
2008
Highly Cited
2008
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour… (More)
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Highly Cited
2008
Highly Cited
2008
A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss.
OBJECTIVE A high-protein diet (HPD) is known to promote the reduction of body fat, but the mechanisms underlying this change are… (More)
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Highly Cited
2001
Highly Cited
2001
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.
Brain-derived neurotrophic factor has been associated previously with the regulation of food intake. To help elucidate the role… (More)
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Highly Cited
1999
Highly Cited
1999
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
Pro-opiomelanocortin (POMC)-derived peptides (the melanocortins adrenocorticotropin, α-, β- and γ-melanocyte stimulating hormone… (More)
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Highly Cited
1998
Highly Cited
1998
Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin.
Reduction in the activity of the alpha-melanocyte-stimulating hormone (alpha-MSH) system causes obesity, and infusions of alpha… (More)
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Highly Cited
1998
Highly Cited
1998
Mice lacking melanin-concentrating hormone are hypophagic and lean
Feeding is influenced by hypothalamic neuropeptides that promote (orexigenic peptides) or inhibit feeding. Of these, neuropeptide… (More)
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Highly Cited
1997
Highly Cited
1997
Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.
Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that act in the brain to reduce food intake… (More)
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