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Primary sclerosing cholangitis

Known as: PSC, Sclerosing Cholangitis, cholangitis primary sclerosing 
A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in… 
National Institutes of Health

Related topics

Related topics

8 relations
Bile duct structureBiliary tract structureCholangitis, SclerosingGastrointestinal system

Broader (2)

Biliary Tract DiseasesStenosing cholangitis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Expandable metal stents for benign biliary disease.
Highly Cited
2001
Highly Cited
2001
A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.
PURPOSE P-glycoprotein is an efflux pump for many drugs including doxorubicin and paclitaxel. This study evaluated the… 
Highly Cited
2001
Highly Cited
2001
Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.
PURPOSE To determine the maximum-tolerated dose, pharmacokinetic interaction, and activity of PSC 833 compared with daunorubicin… 
2001
2001
Hepatobiliary and extra-hepatic malignancies in primary sclerosing cholangitis.
The increased risk for cholangiocarcinoma in primary sclerosing cholangitis (PSC) is well established, but the factors… 
Review
2001
Review
2001
Primary sclerosing cholangitis
Opinion statementThere is no proven medical therapy for primary sclerosing cholangitis. The goal of management should be… 
Review
2001
Review
2001
Natural history and prognostic models in primary sclerosing cholangitis.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the… 
Highly Cited
1997
Highly Cited
1997
Structure and chromosomal assignment of the human cathepsin K gene.
Cathepsin K is a recently identified lysosomal cysteine proteinase that is the major protease responsible for bone resorption and… 
Highly Cited
1996
Highly Cited
1996
p53 Protein overexpression in cholangiocarcinoma arising in primary sclerosing cholangitis.
The protein encoded by the p53 tumour suppressor gene plays an important part in the regulation of cell growth. Abnormalities of… 
Highly Cited
1982
Highly Cited
1982
Primary Sclerosing Cholangitis: Results of an Aggressive Surgical Approach
Traditional management of patients with primary sclerosing cholangitis (PSC) has included steroids and/or choledochotomy plus… 
Review
1982
Review
1982
Primary Sclerosing Cholangitis: A Heterogenous Disease
The clinical, radiologic and pathologic features of 37 patients diagnosed as having primary sclerosing cholangitis (PSC) were… 
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