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Pre-Replication Complex

Known as: pre-replication complex location, pre-replicative complex, pre-replicative complex location 
The Origin Recognition Complex (ORC) in eukaryotic cells selects genomic sites where pre-replication complexes (pre-RCs) can be assembled. Subsequent… 
National Institutes of Health

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Related topics

3 relations
MCM3 protein, humanpre-primosome complexpre-replicative complex location

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Comparative analysis of pre‐replication complex proteins in transformed and normal cells
This study examines the abundance of the major protein constituents of the pre‐replication complex (pre‐RC), both genome‐wide and… 
2012
2012
Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus
Studies of EBV replication origins demonstrate an excess of pre-replication complexes that are formed at flexible MNase-sensitive… 
2012
2012
A Yeast GSK-3 Kinase Mck1 Promotes Cdc6 Degradation to Inhibit DNA Re-Replication
Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replication origins to promote… 
2010
2010
Preferential Re-Replication of Drosophila Heterochromatin in the Absence of Geminin
To ensure genomic integrity, the genome must be duplicated exactly once per cell cycle. Disruption of replication licensing… 
2008
2008
Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly
Cyclin-dependent kinases (CDKs) are important in regulating cell cycle transitions, particularly in coordinating DNA replication… 
Review
2007
Review
2007
DNA Replication and Human Disease
356 NATURE CELL BIOLOGY VOLUME 9 | NUMBER 4 | APRIL 2007 Progress in the field of DNA replication has been astounding in the ten… 
2006
2006
Dynamics of DNA Binding of Replication Initiation Proteins during de Novo Formation of Pre-replicative Complexes in Xenopus Egg Extracts*
We investigated the dynamics of DNA binding of replication initiation proteins during formation of the pre-replicative complex… 
2005
2005
Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress
The regulation of a pre-replicative complex (pre-RC) at origins ensures that the genome is replicated only once per cell cycle… 
Highly Cited
2003
Highly Cited
2003
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
2000
2000
The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins.
In eukaryotes, the initiation of DNA synthesis requires the assembly of a pre-replicative complex (pre-RC) at origins of… 
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