• Publications
  • Influence
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classicalExpand
  • 1,909
  • 117
  • PDF
Virtual and biomolecular screening converge on a selective agonist for GPR30
Estrogen is a hormone critical in the development, normal physiology and pathophysiology1 of numerous human tissues2. The effects of estrogen have traditionally been solely ascribed to estrogenExpand
  • 671
  • 57
  • PDF
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.
Steroids play an important role in the regulation of normal physiology and the treatment of disease. Steroid receptors have classically been described as ligand-activated transcription factorsExpand
  • 528
  • 37
In vivo Effects of a GPR30 Antagonist
Estrogen is central to many physiological processes throughout the human body. We have previously shown that the G protein-coupled receptor GPR30/GPER, in addition to classical nuclear estrogenExpand
  • 390
  • 34
A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: its use in the simultaneous fluorimetric assay of cellular activation processes.
A fluorimetric assay for the indirect determination of superoxide production during the respiratory burst of stimulated polymorphonuclear leukocytes was described. The method allowed theExpand
  • 316
  • 18
Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe*
Background: By integrating extracellular signals with actin cytoskeletal changes, Cdc42 plays important roles in cell physiology and has been implicated in human diseases. Results: A small moleculeExpand
  • 93
  • 15
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
Studies in B cells from Lyn-deficient mice have identified Lyn as both a kinetic accelerator and negative regulator of signaling through the BCR. The signaling properties of bone marrow-derived mastExpand
  • 64
  • 15
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system.
The G protein-coupled receptor 30 (GPR 30) has been identified as the non-genomic estrogen receptor, and G-1, the specific ligand for GPR30. With the use of a polyclonal antiserum directed againstExpand
  • 404
  • 12
  • PDF
The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures
As yeast cultures enter stationary phase in rich, glucose-based medium, differentiation of two major subpopulations of cells, termed quiescent and nonquiescent, is observed. Differences in mRNAExpand
  • 75
  • 12
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.
H2O2, in concentrations achieved in the proximity of stimulated leukocytes, induces injury and lysis of target cells. This may be an important aspect of inflammatory injury of tissues. Cell lysis inExpand
  • 448
  • 11