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Pralatrexate

Known as: Pralatrexato, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid, (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid 
A folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating… Expand
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Highly Cited
2013
Highly Cited
2013
Drought conditions are among the most serious challenges to crop production worldwide. Here, we report the results of field… Expand
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Highly Cited
2012
Highly Cited
2012
The relative contribution of novel fibers such as polydextrose and soluble corn fiber (SCF) to the human gut microbiome and its… Expand
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Highly Cited
2010
Highly Cited
2010
We suggested in 2009 that the Nekrasov function with one non-vanishing deformation parameter is obtained by the standard Seiberg… Expand
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Highly Cited
2005
Highly Cited
2005
During embryogenesis, the pancreas arises from dorsal and ventral pancreatic protrusions from the primitive gut endoderm upon… Expand
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Review
2005
Review
2005
Proprotein convertases (PCs) are a group of Ca2+‐dependent serine proteases that have homology to the endoproteases subtilisin… Expand
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Highly Cited
2003
Highly Cited
2003
PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT Ten chlorate-respiring bacteria were isolated from wastewater and a perchlorate-degrading bioreactor. Eight of the… Expand
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Highly Cited
2001
Highly Cited
2001
The homeobox factor PDX-1 is a key regulator of pancreatic morphogenesis and glucose homeostasis; targeted disruption of the PDX… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT Homeobox (hox) proteins have been shown to regulate cell fate and segment identity by promoting the expression of… Expand
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