Skip to search formSkip to main contentSkip to account menu

Pralatrexate

Known as: Pralatrexato, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid, (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid 
A folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (1)

10-propargyl-10-deazaaminopterin
2 ML Pralatrexate 20 MG/ML Injection [Folotyn]Folic AcidNCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (1)

Folotyn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Core-Shell Structuring of Pure Metallic Aerogels towards Highly Efficient Platinum Utilization for the Oxygen Reduction Reaction.
The development of core-shell structures remains a fundamental challenge for pure metallic aerogels. Here we report the synthesis… 
Review
2016
Review
2016
Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles
Review
2014
Review
2014
Lessons from patient-derived xenografts for better in vitro modeling of human cancer.
Highly Cited
2012
Highly Cited
2012
454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber.
The relative contribution of novel fibers such as polydextrose and soluble corn fiber (SCF) to the human gut microbiome and its… 
Review
2005
Review
2005
Proprotein convertases: “Master switches” in the regulation of tumor growth and progression
Proprotein convertases (PCs) are a group of Ca2+‐dependent serine proteases that have homology to the endoproteases subtilisin… 
Highly Cited
2003
Highly Cited
2003
Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression
PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor… 
Highly Cited
2001
Highly Cited
2001
Kinetics of Perchlorate- and Chlorate-Respiring Bacteria
ABSTRACT Ten chlorate-respiring bacteria were isolated from wastewater and a perchlorate-degrading bioreactor. Eight of the… 
Highly Cited
2001
Highly Cited
2001
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells
Pro-protein convertases such as furin are expressed in many human tumor lines and primary tumors. Furin processes stromelysin-3… 
Highly Cited
2001
Highly Cited
2001
PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.
The homeobox factor PDX-1 is a key regulator of pancreatic morphogenesis and glucose homeostasis; targeted disruption of the PDX… 
Highly Cited
1999
Highly Cited
1999
Pbx-Hox Heterodimers Recruit Coactivator-Corepressor Complexes in an Isoform-Specific Manner
ABSTRACT Homeobox (hox) proteins have been shown to regulate cell fate and segment identity by promoting the expression of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)