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Polycomb-Group Proteins

Known as: Polycomb-Group Protein, Polycomb Group Proteins, Polycomb Repressive Complex Proteins 
A family of proteins that play a role in CHROMATIN REMODELING. They are best known for silencing HOX GENES and the regulation of EPIGENETIC PROCESSES… 
National Institutes of Health

Related topics

Related topics

22 relations
BMI1 protein, humanChromatin Remodeling FactorDNA Topology RegulationEZH2 protein, human

Narrower (3)

Cbx8 protein, mousePolycomb Group (PcG) Multiprotein PRC1-Like Complexpho protein, Drosophila

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors
Polycomb group (PcG) proteins are overexpressed in several human malignancies including breast cancer. In particular, aberrant… 
Highly Cited
2005
Highly Cited
2005
Analysis of a Polycomb Group Protein Defines Regions That Link Repressive Activity on Nucleosomal Templates to In Vivo Function
ABSTRACT Polycomb group (PcG) genes propagate patterns of transcriptional repression throughout development. The products of… 
Highly Cited
2002
Highly Cited
2002
Transcription through the iab-7 cis-regulatory domain of the bithorax complex interferes with maintenance of Polycomb-mediated silencing.
The Fab-7 chromatin domain boundary insures functional autonomy of the iab-6 and iab-7 cis-regulatory domains in the bithorax… 
Highly Cited
2002
Highly Cited
2002
Pleiohomeotic Can Link Polycomb to DNA and Mediate Transcriptional Repression
ABSTRACT Polycomb group (PcG) proteins function through cis-acting DNA elements called PcG response elements (PREs) to stably… 
Review
2001
Review
2001
Chromatin silencing and activation by Polycomb and trithorax group proteins
The Polycomb group (PcG) of repressors and the trithorax group (trxG) of activators maintain the correct expression of several… 
Highly Cited
2001
Highly Cited
2001
Site-Specific Recognition of a 70-Base-Pair Element Containing d(GA)n Repeats Mediatesbithoraxoid Polycomb Group Response Element-Dependent Silencing
ABSTRACT Polycomb group proteins act through Polycomb group response elements (PREs) to maintain silencing at homeotic loci. The… 
Highly Cited
1998
Highly Cited
1998
Stage-specific expression of polycomb group genes in human bone marrow cells.
Mammalian Polycomb group (Pc-G) genes, constituting some 5 subfamilies based on their identity to the Drosophila genes Pc, Psc… 
Highly Cited
1998
Highly Cited
1998
Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes
ABSTRACT The Polycomb group (Pc-G) constitutes an important, functionally conserved group of proteins, required to stably… 
Highly Cited
1998
Highly Cited
1998
Genetic interactions and dosage effects of Polycomb group genes in mice.
In Drosophila and mouse, Polycomb group genes are involved in the maintenance of homeotic gene expression patterns throughout… 
Highly Cited
1997
Highly Cited
1997
Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis
Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here… 
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