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Poly (ADP-Ribose) Polymerase-1

Known as: Poly (ADP-Ribose) Synthase-1, PARP-1 Protein, PARP 1 Protein 
A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin… 
National Institutes of Health

Related topics

Related topics

16 relations
ADP Ribose TransferasesIn BloodMono(ADP-Ribose) TransferasesNAD+ ADP-Ribosyltransferase

Narrower (3)

Adprt protein, ratPARP1 protein, humanParp1 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Effect of exercise on telomere length and telomere proteins expression in mdx mice
In Duchenne muscular dystrophy (DMD), telomere shortening has been postulated to contribute to the failure of regenerative… 
2019
2019
Discovery of naphthacemycins as a novel class of PARP1 inhibitors.
2017
2017
Structural modeling of NAD+ binding modes to PARP-1
The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1… 
2017
2017
Neuroprotective Epigenetic and DNA Damage Repairing Molecular Mechanisms of L-Carnitine and its Congeners against Aging and Age-Related Neurodegenerative Diseases
Aging is an ubiquitous biological phenomena characterized by ever-increasing susceptibility to diseases due to increased… 
2016
2016
Combination therapy with enzalutamide and the poly (ADP-ribose) polymerase-1 (PARP1) inhibitor niraparib in castration-resistant prostate cancer (CRPC): HCRN GU 14-202.
TPS5095Background: PARP1 is a multi-functional enzyme implicated in DNA repair and transcription factor regulation. It regulates… 
Review
2015
Review
2015
Poly(ADP)-Ribose Polymerase-1 Inhibitors as a Potential Treatment for Cocaine Addiction.
As of 2008, according to the National Survey on Drug Use and Health, nearly 1.4 million Americans met the Diagnostic and… 
2015
2015
The nuclear expression of poly (ADP-ribose) polymerase-1 (PARP1) in invasive primary breast tumors is associated with chemotherapy sensitivity.
2012
2012
Immunohisochemical study of BRCA1, BRCA2, and poly (ADP-ribose) polymerase-1 in ovarian tumors
Negative expression of BRCA1 and BRCA2 was found in 12.5% and 22.5% of benign tumors, 25.0% and 33.3% of borderline tumors, and… 
2009
2009
Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway.
alpha-Synuclein (ASN) is a brain-enriched protein that functions as a molecular chaperone and regulator of the synaptic vesicle… 
Review
2006
Review
2006
Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs.
Novel substituted triptycene bisquinones and 1, 4-anthracenediones were synthesized and screened for their anti-cancer activities… 
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