Poloxamer

Known as: Poloxamer [Chemical/Ingredient], alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene)a block copolymer 
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different… (More)
National Institutes of Health

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33 relations

Narrower (23)

LeGooLumagelNB-402 nanoemulsionOrthoblast II
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Broader (3)

Pharmaceutical ExcipientPoloxamersSurface-Active Agents
PoloxalenePoloxamer 182analogs & derivativesaspects of radiation effects
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Papers overview

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2011
2011
Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel.
Fungal keratitis is a serious disease that can lead to loss of vision. Unfortunately, current therapeutic options often result in… (More)
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Highly Cited
2010
Highly Cited
2010
A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery.
The aim of the present work was to obtain an ophthalmic delivery system with improved mechanical and mucoadhesive properties that… (More)
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2008
2008
A novel poloxamers/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties.
The influence of hyaluronic acid (HA) on the gelation properties of poloxamers blends has been studied with the aim of… (More)
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Highly Cited
2007
Highly Cited
2007
Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers.
Role of various water-soluble carriers was studied for dissolution enhancement of a poorly soluble model drug, rofecoxib, using… (More)
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2007
2007
Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin.
Conventional ophthalmic solutions often eliminate rapidly after administration and cannot provide and maintain an adequate… (More)
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Highly Cited
2005
Highly Cited
2005
Sustained release of lidocaine from Poloxamer 407 gels.
In this work, we show that alteration of P407 gel content can affect drug release rates. The inorganic salts and PEG 400 commonly… (More)
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2005
2005
Caprolactonic poloxamer analog: PEG-PCL-PEG.
The aqueous solution of poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG) triblock copolymers (> 15… (More)
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Highly Cited
2001
Highly Cited
2001
Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium.
Liquid suppository systems composed of poloxamers and bioadhesive polymers were easy to administer to the anus and mucoadhesive… (More)
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1999
1999
Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS.
The surface chemical characterisation of sub-200 nm poly(DL-lactide co-glycolide) nanospheres has been carried out using the… (More)
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Highly Cited
1998
Highly Cited
1998
Rheological evaluation of poloxamer as an in situ gel for ophthalmic use.
The contact time of a vehicle on the cornea is of utmost importance for ocular drug delivery. In the present study rheological… (More)
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