LeGoo
National Institutes of Health
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......................................................................................................................................... 2 Acknowledgements ...................................................................................................................... 12 Funding Sources ........................................................................................................................... 13 Publications, Prizes and Presentations ........................................................................................ 14 Journal Publications ................................................................................................................. 14 Prizes ........................................................................................................................................ 14 Presentations ........................................................................................................................... 14 Abbreviations ............................................................................................................................... 16 List of Tables, Figures and Equations ........................................................................................... 20 Tables ........................................................................................................................................... 20 Figures .......................................................................................................................................... 20 Equations...................................................................................................................................... 25 1. Chapter 1; Introduction and Literature Review ................................................................... 26 1.1. Anatomy, physiology and pathophysiology of the lung and COPD ............................. 27 1.1.1. Anatomy of the lung............................................................................................. 27 1.1.2. Physiology of the lung .......................................................................................... 28 1.1.3. Chronic Obstructive Pulmonary Disease and its pathophysiology ...................... 30 1.2. Chronic Obstructive Pulmonary Disease today: management options and limitations 34 1.2.1. Pharmacotherapy ................................................................................................. 34 1.2.2. Lung volume reduction strategies ........................................................................ 36 1.2.3. Lung transplantation ............................................................................................ 39 1.3. Future approaches to COPD treatment – regenerative medicine (RM) and tissue engineering (TE) ....................................................................................................................... 39 1.3.1. Cell sources for potential use in respiratory regeneration .................................. 40 1.3.1.1. Endogenous stem cell populations of the respiratory tract ........................ 40 1.3.1.2. Exogenous stem cells for regenerative purposes: MSCs ............................. 41 1.3.2. Signalling factors for potential respiratory regeneration .................................... 45 1.3.2.1. Hepatocyte Growth Factor (HGF) ................................................................ 45 1.3.2.2. Bone Morphogenetic Protein 4 (BMP-4) ..................................................... 46
Sanofi has agreed to buy the US medical device company Pluromed in order to strengthen the biosurgery portfolio it gained via its…
The Food and Drug Administration has approved LeGoo, a gel that allows surgeons to stop blood without clamps or elastic loops so…
To evaluate the safety and efficacy of a novel, reverse thermo-sensitive polymer (LeGoo) for its ability to provide temporary…