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Polo-Box Domain

Members of the polo subfamily of protein kinases appear to play pivotal roles in cell division and proliferation. These include mammalian Plk, Snk… 
National Institutes of Health

Related topics

Related topics

4 relations
PLK1 protein, humanPLK2 protein, humanPLK3 protein, humanPLK4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Design, synthesis and evaluation of d-amino acid-containing peptidomimetics targeting the polo-box domain of polo-like kinase 1.
2019
2019
DITMD‐induced mitotic defects and apoptosis in tumor cells by blocking the polo‐box domain‐dependent functions of polo‐like kinase 1
2019
2019
Identification of novel peptidomimetics targeting the polo-box domain of polo-like kinase 1.
2017
2017
The 10th Annual Frontiers in Chemistry and Biology Interface
Multi-domain proteins often require help from molecular chaperones to fold productively, even before the ribosome has finished… 
2016
2016
Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response*
At the onset of anaphase, a protease called separase breaks the link between sister chromatids by cleaving the cohesin subunit… 
2015
2015
Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity–dependent suicidal inhibition of its polo-box domain
Polo-like kinase 1 (Plk1) plays a critical role in proper M-phase progression and cell proliferation. Plk1 is overexpressed in a… 
2013
2013
Molecular and Cellular Pathobiology CIP 2 A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk 1
Abnormal cell-cycle control can lead to aberrant cell proliferation and cancer. The oncoprotein cancerous inhibitor of protein… 
2012
2012
Therapeutic Discovery Targeting Subcellular Localization through the Polo-Box Domain : Non-ATP Competitive Inhibitors Recapitulate a PLK 1 Phenotype
The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1 (PLK1). The replacement with partial… 
2011
2011
Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries.
Phosphopeptide binding domains mediate the directed and localized assembly of protein complexes essential to intracellular kinase… 
Review
2009
Review
2009
A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).
The Polo-like kinase (Plk) family comprises four cell cycle serine/threonine kinases, Plk1-4. Among these, Plk1 has been most… 
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