Polo-Box Domain

Members of the polo subfamily of protein kinases appear to play pivotal roles in cell division and proliferation. These include mammalian Plk, Snk… (More)
National Institutes of Health

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2015
2015
Recent progress in the development of peptide-derived Polo-like kinase (Plk1) polo-box domain (PBD) inhibitors has led to the… (More)
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2015
2015
Polo-like kinase 2 (PLK2) is a crucial regulator in cell cycle progression, DNA damage response, and neuronal activity. PLK2 is… (More)
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2013
2013
The polo-box domain (PBD) of polo-like kinase 1 (Plk1) is essentially required for the function of Plk1 in cell proliferation… (More)
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2013
2013
BACKGROUND Over the years, a great deal of effort has been focused on the design and synthesis of potent, linear peptide… (More)
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2012
2012
The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1 (PLK1). The replacement with partial… (More)
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2012
2012
Polo-like kinase 1 (Plk1) is a regulator of cell cycle progression during mitosis; it is overexpressed in many different tumors… (More)
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2009
2009
Polo-like kinase-1 (Plk1) has a pivotal role in cell proliferation and is considered a potential target for anticancer therapy… (More)
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Highly Cited
2008
Highly Cited
2008
The serine/threonine kinase Polo-like kinase 1 (Plk1) is overexpressed in many types of human cancers, and has been implicated as… (More)
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Highly Cited
2006
Highly Cited
2006
Polo-like kinase 1 (Plk1) has multiple important functions during M-phase progression. In addition to a catalytic domain, Plk1… (More)
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Highly Cited
2006
Highly Cited
2006
The polo-box domain (PBD) of mammalian polo-like kinase 1 (Plk1) is essential in targeting its catalytic activity to specific… (More)
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