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Platelet-Derived Growth Factor Receptor Beta, Human

Known as: EC 2.7.1.112, CD140 Antigen-Like Family Member B, PDGFR-1 
Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine… 
National Institutes of Health

Related topics

Related topics

26 relations
Cell Differentiation processCell ProliferationEnzyme GeneHomo sapiens

Broader (2)

Platelet-Derived Growth Factor beta ReceptorProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Characterization of Pdgfrb‐Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries
With the intention to modulate gene expression in vascular mural cells of remodeling vessels, we generated and characterized… 
Highly Cited
2010
Highly Cited
2010
Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model.
Chronic hypoxia contributes to pulmonary hypertension through complex mechanisms that include enhanced NADPH oxidase expression… 
Highly Cited
2010
Highly Cited
2010
Design of an optimized scaffold for affibody molecules.
Highly Cited
2009
Highly Cited
2009
Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer.
PURPOSE Sorafenib is an oral multikinase inhibitor that targets the Ras/Raf/MEK/ERK mitogenic signaling pathway and the… 
Highly Cited
2008
Highly Cited
2008
Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells
Purpose: Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of urothelial carcinoma, but a… 
Highly Cited
2007
Highly Cited
2007
In Situ Detection of Phosphorylated Platelet-derived Growth Factor Receptor β Using a Generalized Proximity Ligation Method*
Improved methods are needed for in situ characterization of post-translational modifications in cell lines and tissues. For… 
Highly Cited
2006
Highly Cited
2006
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
In bone metastatic lesions, osteoclasts play a key role in the development of osteolysis. Previous studies have shown that… 
Highly Cited
2000
Highly Cited
2000
Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain.
Integrin-mediated cell attachment and growth factor stimulation often act synergistically on cell proliferation, differentiation… 
Highly Cited
1993
Highly Cited
1993
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64…
Binding of platelet-derived growth factor (PDGF) to the PDGF receptor (PDGFR) beta subunit triggers receptor tyrosine… 
Highly Cited
1992
Highly Cited
1992
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
In response to binding of platelet-derived growth factor (PDGF), the PDGF receptor (PDGFR) beta subunit is phosphorylated on… 
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