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Inherited deficiencies of the L-lysine catabolic pathway cause glutaric aciduria type I and pyridoxine-dependent epilepsy… Expand The Lys catabolite pipecolic acid (Pip) is identified as a critical signal for several forms of inducible plant immunity, acting… Expand The potential of proline to suppress reactive oxygen species (ROS) and apoptosis in mammalian cells was tested by manipulating… Expand Amino acid homeostasis depends on specific amino acid transport systems, many of which have been characterized at the molecular… Expand Sarcosine oxidase (SOX) is known as a peroxisomal enzyme in mammals and as a sarcosine-inducible enzyme in soil bacteria. Its… Expand In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate… Expand IV. Overview of Genetic Changes in PKS Genes 2565 A. Changes in â-Carbonyl Processing 2565 1. Loss of Function 2565 2. Gain of… Expand An open reading frame (rapP) encoding the putative pipecolate-incorporating enzyme (PIE) has been identified in the gene cluster… Expand Immunomycin, an immunosuppressant closely related to FK 506, contains a pipecolate residue in amide linkage with an acyl group in… Expand Employing both the intraventricular and intraperitoneal injection techniques, 14C‐l‐lysine at non‐overloading concentrations was… Expand