Molecular cloning and expression of human L-pipecolate oxidase.

@article{Ijlst2000MolecularCA,
  title={Molecular cloning and expression of human L-pipecolate oxidase.},
  author={L. Ijlst and I. de Kromme and W. Oostheim and R. Wanders},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={270 3},
  pages={
          1101-5
        }
}
In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate pathway. The saccharopine pathway is the primary route of degradation of lysine in most tissues except the brain in which the L-pipecolate pathway is most active. L-pipecolate is formed from L-lysine via two enzymatic reactions and then undergoes dehydrogenation to Delta(1)-piperideine-6-carboxylate. At least in humans and monkeys, this is brought about by the enzyme L… Expand
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