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Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Known as:
Ribonucleotide Transformylase, Aminoimidazolecarboxamide
, Transformylase, AICAR
, Formyltransferase, AICAR
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An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the…
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National Institutes of Health
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Related topics
Related topics
14 relations
ATIC gene
Cytoplasmic matrix
Enzyme Gene
Hydrolysis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
T. Boritzki
,
C. Barlett
,
+5 authors
R. Jackson
Investigational new drugs
2004
Corpus ID: 5687386
SummaryThe glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5…
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1999
1999
Catalytic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies.
J. H. Shim
,
S. Benkovic
Biochemistry
1999
Corpus ID: 40771996
Site-directed mutagenesis followed by studies of the pH dependence of the kinetic parameters of the mutants has been used to…
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Highly Cited
1997
Highly Cited
1997
Formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri - new insights into salt-dependence and thermostability.
U. Ermler
,
M. Merckel
,
R. Thauer
,
S. Shima
Structure
1997
Corpus ID: 23976254
1988
1988
Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells.
J. Baram
,
B. Chabner
,
J. Drake
,
A. Fitzhugh
,
P. Sholar
,
C. Allegra
Journal of Biological Chemistry
1988
Corpus ID: 40675632
Highly Cited
1986
Highly Cited
1986
The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide.
M. Donnelly
,
R. Wolfe
Journal of Biological Chemistry
1986
Corpus ID: 41738619
1984
1984
The transformylase enzymes of de novo purine biosynthesis
S. Benkovic
1984
Corpus ID: 39555269
Highly Cited
1981
Highly Cited
1981
On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver.
W. T. Mueller
,
S. Benkovic
Biochemistry
1981
Corpus ID: 39397983
The transformylase from chicken liver catalyzing the formylation of 5-aminoimidazole-4-carboxamide ribonucleotide through the…
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Highly Cited
1981
Highly Cited
1981
On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver.
G. K. Smith
,
W. T. Mueller
,
P. Benkovic
,
S. Benkovic
Biochemistry
1981
Corpus ID: 33324537
Tests of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and glycinamide ribonucleotide (GAR) transformylase cofactor…
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Highly Cited
1980
Highly Cited
1980
Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis.
G. K. Smith
,
W. T. Mueller
,
G. Wasserman
,
W. Taylor
,
S. Benkovic
Biochemistry
1980
Corpus ID: 44411078
Evidence is presented for a functional association of GAR TFase and the trifunctional protein within the protein complex…
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Highly Cited
1979
Highly Cited
1979
Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase.
J. Baggott
,
C. Krumdieck
Biochemistry
1979
Corpus ID: 30450542
N10-Formyltetrahydropteroylpoly-gamma-glutamates (N10-formyl-H4PteGlun) having n = 1, 3, 4, 5, 6, and 7 glutamyl residues have…
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