Skip to search formSkip to main contentSkip to account menu

Phosphoribosylaminoimidazolecarboxamide Formyltransferase

Known as: Ribonucleotide Transformylase, Aminoimidazolecarboxamide, Transformylase, AICAR, Formyltransferase, AICAR 
An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the… 
National Institutes of Health

Related topics

Related topics

14 relations
ATIC geneCytoplasmic matrixEnzyme GeneHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase
SummaryThe glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5… 
1999
1999
Catalytic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies.
Site-directed mutagenesis followed by studies of the pH dependence of the kinetic parameters of the mutants has been used to… 
Highly Cited
1997
Highly Cited
1997
Formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri - new insights into salt-dependence and thermostability.
1988
1988
Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells.
Highly Cited
1986
Highly Cited
1986
The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide.
1984
1984
The transformylase enzymes of de novo purine biosynthesis
Highly Cited
1981
Highly Cited
1981
On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver.
The transformylase from chicken liver catalyzing the formylation of 5-aminoimidazole-4-carboxamide ribonucleotide through the… 
Highly Cited
1981
Highly Cited
1981
On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver.
Tests of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and glycinamide ribonucleotide (GAR) transformylase cofactor… 
Highly Cited
1980
Highly Cited
1980
Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis.
Evidence is presented for a functional association of GAR TFase and the trifunctional protein within the protein complex… 
Highly Cited
1979
Highly Cited
1979
Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase.
N10-Formyltetrahydropteroylpoly-gamma-glutamates (N10-formyl-H4PteGlun) having n = 1, 3, 4, 5, 6, and 7 glutamyl residues have… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)