Phosphoribosylaminoimidazolecarboxamide Formyltransferase

Known as: Ribonucleotide Transformylase, Aminoimidazolecarboxamide, Transformylase, AICAR, Formyltransferase, AICAR 
An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the… (More)
National Institutes of Health

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14 relations
ATIC geneCytoplasmic matrixEnzyme GeneHydrolysis
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Papers overview

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2009
2009
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of…
Anaplastic large cell lymphoma represents a subset of neoplasms caused by translocations that juxtapose the anaplastic lymphoma… (More)
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2009
2009
Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.
Although purines and purinergic signaling are crucial for numerous biochemical and cellular processes, their functions during… (More)
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Highly Cited
2006
Highly Cited
2006
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
OBJECTIVE Methotrexate (MTX) is an antifolate agent that is often associated with toxicity. This study investigated whether risk… (More)
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2004
2004
AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.
In a female infant with dysmorphic features, severe neurological defects, and congenital blindness, a positive urinary Bratton… (More)
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2001
2001
Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides.
Incremental truncation for the creation of hybrid enzymes (ITCHY) is a novel tool for the generation of combinatorial libraries… (More)
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Highly Cited
2000
Highly Cited
2000
ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
The subset of CD30-positive anaplastic large cell lymphomas (ALCL) with the NPM-ALK gene fusion arising from the t(2;5)(p23;q35… (More)
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Highly Cited
2000
Highly Cited
2000
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
Anaplastic lymphoma kinase (ALK)-positive lymphomas ("ALKomas") constitute a distinct molecular and clinicopathological entity… (More)
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Highly Cited
2000
Highly Cited
2000
Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide…
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that… (More)
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Highly Cited
1986
Highly Cited
1986
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4…
With the use of a continuous spectrophotometric assay and initial rates determined by the method of Waley [Biochem. J. (1981) 193… (More)
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Highly Cited
1985
Highly Cited
1985
Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic… (More)
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