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Phosphoribosylaminoimidazolecarboxamide Formyltransferase

Known as: Ribonucleotide Transformylase, Aminoimidazolecarboxamide, Transformylase, AICAR, Formyltransferase, AICAR 
An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the… Expand
National Institutes of Health

Related topics

Related topics

14 relations
ATIC geneCytoplasmic matrixEnzyme GeneHydrolysis
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Probing the ATIC peak in the cosmic-ray electron spectrum with H.E.S.S.
The measurement of an excess in the cosmic-ray electron spectrum between 300 and 800 GeV by the ATIC experiment has - together… Expand
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Highly Cited
2008
Highly Cited
2008
Decaying dark matter can explain the e? excesses
PAMELA and ATIC recently reported excesses in e± cosmic rays. Since the interpretation in terms of DM annihilations was found to… Expand
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Highly Cited
2006
Highly Cited
2006
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
OBJECTIVE Methotrexate (MTX) is an antifolate agent that is often associated with toxicity. This study investigated whether risk… Expand
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Highly Cited
2000
Highly Cited
2000
ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
The subset of CD30-positive anaplastic large cell lymphomas (ALCL) with the NPM-ALK gene fusion arising from the t(2;5)(p23;q35… Expand
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Highly Cited
2000
Highly Cited
2000
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
Anaplastic lymphoma kinase (ALK)-positive lymphomas ("ALKomas") constitute a distinct molecular and clinicopathological entity… Expand
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Highly Cited
2000
Highly Cited
2000
Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide…
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that… Expand
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Highly Cited
1991
Highly Cited
1991
Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase.
We have investigated the structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDATHF) that determine the activity of… Expand
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Highly Cited
1987
Highly Cited
1987
Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
We have investigated the role of dihydrofolate (H2PteGlu) accumulation in the inhibition of de novo purine synthesis by… Expand
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Highly Cited
1986
Highly Cited
1986
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4…
With the use of a continuous spectrophotometric assay and initial rates determined by the method of Waley [Biochem. J. (1981) 193… Expand
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Highly Cited
1985
Highly Cited
1985
Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic… Expand
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