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Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Known as:
Ribonucleotide Transformylase, Aminoimidazolecarboxamide
, Transformylase, AICAR
, Formyltransferase, AICAR
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An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the…
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National Institutes of Health
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Related topics
Related topics
14 relations
ATIC gene
Cytoplasmic matrix
Enzyme Gene
Hydrolysis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Probing the ATIC peak in the cosmic-ray electron spectrum with H.E.S.S.
H. C. Aharonian
,
E. al.
2009
Corpus ID: 55992961
The measurement of an excess in the cosmic-ray electron spectrum between 300 and 800 GeV by the ATIC experiment has - together…
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Highly Cited
2008
Highly Cited
2008
Decaying dark matter can explain the e? excesses
E. Nardi
,
Francesco Sannino
,
A. Strumia
2008
Corpus ID: 15711899
PAMELA and ATIC recently reported excesses in e± cosmic rays. Since the interpretation in terms of DM annihilations was found to…
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Highly Cited
2008
Highly Cited
2008
Astrophysical probes of unification
A. Arvanitaki
,
S. Dimopoulos
,
S. Dubovsky
,
P. Graham
,
R. Harnik
,
S. Rajendran
2008
Corpus ID: 10614492
Traditional ideas for testing unification involve searching for the decay of the proton and its branching modes. We point out…
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Highly Cited
2006
Highly Cited
2006
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
M. Weisman
,
D. Furst
,
+5 authors
Thierry Dervieux
Arthritis & Rheumatism
2006
Corpus ID: 46377086
OBJECTIVE Methotrexate (MTX) is an antifolate agent that is often associated with toxicity. This study investigated whether risk…
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Highly Cited
2004
Highly Cited
2004
AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.
S. Marie
,
B. Héron
,
P. Bitoun
,
Therese Timmerman
,
G. van den Berghe
,
M. Vincent
American Journal of Human Genetics
2004
Corpus ID: 7494129
In a female infant with dysmorphic features, severe neurological defects, and congenital blindness, a positive urinary Bratton…
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Highly Cited
2000
Highly Cited
2000
ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
Gisele W. B. Colleoni
,
J. Bridge
,
+4 authors
M. Ladanyi
American Journal of Pathology
2000
Corpus ID: 32232735
Highly Cited
2000
Highly Cited
2000
Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide…
Zhigui Ma
,
J. Cools
,
+8 authors
S. Morris
Blood
2000
Corpus ID: 10339722
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that…
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Highly Cited
1987
Highly Cited
1987
Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
Carmen J. Allegra
,
K. Hoang
,
Grace Chao Yeh
,
James C. Drake
,
J. Baram
Journal of Biological Chemistry
1987
Corpus ID: 25246458
Highly Cited
1986
Highly Cited
1986
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4…
J. Baggott
,
W. Vaughn
,
B. Hudson
Biochemical Journal
1986
Corpus ID: 2030321
With the use of a continuous spectrophotometric assay and initial rates determined by the method of Waley [Biochem. J. (1981) 193…
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Highly Cited
1985
Highly Cited
1985
Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.
C. Allegra
,
J. Drake
,
J. Jolivet
,
B. Chabner
Proceedings of the National Academy of Sciences…
1985
Corpus ID: 43419521
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic…
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