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Phosphoribosylaminoimidazolecarboxamide Formyltransferase

Known as: Ribonucleotide Transformylase, Aminoimidazolecarboxamide, Transformylase, AICAR, Formyltransferase, AICAR 
An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the… 
National Institutes of Health

Related topics

Related topics

14 relations
ATIC geneCytoplasmic matrixEnzyme GeneHydrolysis

Papers overview

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Highly Cited
2008
Highly Cited
2008
Case for a 700+GeV WIMP: Cosmic ray spectra from PAMELA, Fermi, and ATIC
Multiple lines of evidence indicate an anomalous injection of high-energy e{sup +}e{sup -} in the galactic halo. The recent e{sup… 
Highly Cited
2008
Highly Cited
2008
Discriminating different scenarios to account for the cosmic e ± excess by synchrotron and inverse Compton radiation
The excesses of the cosmic positron fraction recently measured by PAMELA and the electron spectra by ATIC, PPB-BETS, Fermi, and H… 
Highly Cited
2008
Highly Cited
2008
Decaying Hidden Gauge Boson and the PAMELA and ATIC/PPB-BETS Anomalies
We show that the PAMELA anomaly in the positron fraction as well as the ATIC/PPBBETS excesses in the e − +e + flux are… 
Highly Cited
2005
Highly Cited
2005
Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization.
Highly Cited
2001
Highly Cited
2001
Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair… 
Highly Cited
1996
Highly Cited
1996
The Human purH Gene Product, 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase
We report here the cloning and sequencing of the cDNA, purification, steady state kinetic analysis, and truncation mapping… 
Highly Cited
1991
Highly Cited
1991
Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase.
We have investigated the structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDATHF) that determine the activity of… 
Highly Cited
1990
Highly Cited
1990
De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide…
The trifunctional enzyme encoding glycinamide ribonucleotide synthetase (GARS)-aminoimidazole ribonucleotide synthetase (AIRS… 
Highly Cited
1986
Highly Cited
1986
The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide.
Highly Cited
1979
Highly Cited
1979
Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase.
N10-Formyltetrahydropteroylpoly-gamma-glutamates (N10-formyl-H4PteGlun) having n = 1, 3, 4, 5, 6, and 7 glutamyl residues have… 
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