Phosphoribosyl Pyrophosphate

To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human… Expand

Primary transcripts of certain microRNA (miRNA) genes are subject to RNA editing that converts adenosine to inosine. However, the… Expand

We have identified missense mutations at conserved amino acids in the PRPS1 gene on Xq22.3 in two families with a syndromic form… Expand

Using a transgene-based screening, we previously isolated several Arabidopsis mutants defective in protein import into… Expand

We report the synthesis of 1'-deoxy-1'-(benzimidazol-1-yl)-beta-D-ribofuranose 7 and 1'-deoxy-1'-phenyl-beta-D-ribofuranose 2… Expand

The structure of the viscous extracellular polysaccharide (glycan) of desiccation-tolerant Nostoc commune DRH-1 was determined… Expand

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. The rate-limiting step in this… Expand

Recent studies have shown that pyrroline 5-carboxylate, the intermediate in the interconversions of proline, ornithine, and… Expand

Plasmodium falciparum trophozoites were isolated by mechanical rupture of infected human erythrocytes followed by a series of… Expand

WE have formulated a structure for the nucleic acids which is compatible with the main features of the X-ray diagram and with the… Expand