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Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 Isoform 3

Known as: Truncated INPP5D, Short-SHIP, SIP-110 
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3 (976 aa, ~109 kDa) is encoded by the human INPP5D gene. This protein plays a role… 
National Institutes of Health

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DephosphorylationEnzyme GeneEsterase GeneHydrolase

Papers overview

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2019
2019
s-SHIP Promoter Expression Identifies Mouse Mammary Cancer Stem Cells
2016
2016
s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells
Isolation of prostate stem cells (PSCs) is crucial for understanding their biology during normal development and tumorigenesis… 
2011
2011
An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.
In a recessive ENU mutagenesis screen for embryonic lethality, we identified a mouse pedigree with a missense mutation of SHIP1… 
Highly Cited
2010
Highly Cited
2010
s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue.
Mammary stem cells (MaSCs) play critical roles in normal development and perhaps tumorigenesis of the mammary gland. Using… 
2006
2006
s-SHIP associates with receptor complexes essential for pluripotent stem cell growth and survival.
Embryonic stem (ES) cells are pluripotent cells that have the ability to either self-renew or differentiate into any cell type… 
2005
2005
The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo.
Highly Cited
2001
Highly Cited
2001
Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein.
SH2-containing inositol 5'-phosphatase (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc… 
Review
1998
Review
1998
Identification and Characterization of an Essential Family of Inositol Polyphosphate 5-Phosphatases ( INP 51 , INP 52 and INP 53 Gene Products ) in the Yeast Saccharomyces cerevisiae
We recently demonstrated that the S. cerevisiae INP51 locus (YIL002c) encodes an inositol polyphosphate 5-phosphatase. Here we… 
1997
1997
Signaling Inositol Polyphosphate-5-phosphatase
An inositol polyphosphate-5-phosphatase (SIP-110) that binds the SH3 domains of the adaptor protein GRB2 was produced in Sf9… 
Highly Cited
1996
Highly Cited
1996
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
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