• Publications
  • Influence
Barrett's esophagus. A prevalent, occult complication of gastroesophageal reflux disease.
A prospective study of patients with symptoms of gastroesophageal reflux was undertaken to determine the prevalence of Barrett's esophagus and reevaluate the diagnostic approach necessary to detectExpand
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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
  • Q. Zhao, G. Rank, +9 authors S. Jane
  • Medicine, Biology
  • Nature Structural &Molecular Biology
  • 22 February 2009
Mammalian gene silencing is established through methylation of histones and DNA, although the order in which these modifications occur remains contentious. Using the human β-globin locus as a model,Expand
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Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.
Scl and Lyl1 encode two related basic-helix-loop-helix transcription factors implicated in T cell acute lymphoblastic leukemia. Previous studies showed that Scl is essential for embryonic and adultExpand
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The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
Gene targeting studies have shown that the transcription factor SCL is critically important for embryonic hematopoiesis, but the early lethality of SCL null mice has precluded the genetic analysis ofExpand
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The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
It's All About Self-Renewal The Lmo2 oncogene was identified as a contributing factor in human T cell acute lymphoblastic leukemia (T-ALL) nearly two decades ago, but the gene rose to prominence inExpand
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Prospective Analysis of Incidence and Risk Factors of Dysphagia in Spine Surgery Patients: Comparison of Anterior Cervical, Posterior Cervical, and Lumbar Procedures
Study Design. A 3-year prospective, cohort study. Objectives. To compare the incidence and risk factors of dysphagia after anterior cervical (AC), posterior cervical (PC), and posterior lumbar (PL)Expand
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Communicating Ecology Through Art: What Scientists Think
Many environmental issues facing society demand considerable public investment to reverse. However, this investment will only arise if the general community is supportive, and community support isExpand
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Towards ecological sustainability: observations on the role of the arts
This paper describes how the arts shape environmental behaviour of individuals and society and is a synthesis arising from a program of previous publication. The literature suggests that the arts mayExpand
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Chronic airflow obstruction in long-term survivors of allogeneic bone marrow transplantation.
Prospective pulmonary function tests (PFTs) of 49 long-term survivors of identical sibling bone marrow transplants (BMT) were analysed. Eight (16%) developed a persistent pulmonary syndromeExpand
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Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation.
Hmgb3 is a member of a family of chromatin-binding proteins that can alter DNA structure to facilitate transcription factor binding. We identified the Hmgb3 cDNA in a subtractive hybridization screenExpand
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